Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.40 |
| ▸ | HTR1F | P30939 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL428478 | 0.84 | NPC1 (0.49) | ALDH1A1SMN1; SMN2NPC1GAARAB9A | |
| SCHEMBL12579446 | 0.76 | TRPA1 (0.44) | ALDH1A1SMN1; SMN2NPC1GAARAB9A | |
| SCHEMBL23539571 | 0.74 | ALDH1A1 (0.63) | ALDH1A1SMN1; SMN2GAARAB9AKDM4E | |
| SCHEMBL108305 | 0.74 | P2RX7 (0.50) | ALDH1A1SMN1; SMN2NPC1GAARAB9A | |
| SCHEMBL25369351 | 0.74 | GAA (0.55) | ALDH1A1SMN1; SMN2NPC1GAARAB9A | |
| SCHEMBL31698755 | 0.74 | GAA (0.55) | ALDH1A1SMN1; SMN2NPC1GAARAB9A | |
| SCHEMBL23708908 | 0.73 | CNR1 (0.46) | ALDH1A1SMN1; SMN2NPC1GAARAB9A | |
| SCHEMBL29503927 | 0.73 | ANO1 (0.47) | ALDH1A1SMN1; SMN2NPC1GAARAB9A | |
| SCHEMBL19249270 | 0.73 | GRM5 (0.55) | ALDH1A1SMN1; SMN2NPC1GAARAB9A | |
| SCHEMBL6419679 | 0.73 | ANO1 (0.47) | ALDH1A1SMN1; SMN2NPC1GAARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127459-A1 | GPR139 RECEPTOR MODULATORS | BLACKTHORN THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |
| WO-2021127459-A1 | GPR139 RECEPTOR MODULATORS | BLACKTHORN THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |