SCHEMBL2354078

SCHEMBL2354078

CCOC(=O)CCc1ccc(OCc2cccc(Oc3ccccc3)c2)c(C)c1

nearest known ligand 0.80

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
FFAR4 Q5NUL3 13/20 0.80
FFAR1 O14842 11/20 0.80
APP P05067 1/20 0.48
AKR1C3 P42330 1/20 0.48
GPR34 Q9UPC5 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2351232 0.92 FFAR1 (0.68) FFAR4FFAR1AKR1C3
SCHEMBL2354357 0.90 FFAR4 (0.64) FFAR4FFAR1AKR1C3
SCHEMBL2350166 0.90 FFAR1 (0.64) FFAR4FFAR1APPAKR1C3GPR34
SCHEMBL2354859 0.89 FFAR4 (1.00) FFAR4FFAR1
SCHEMBL12394709 0.88 FFAR4 (0.85) FFAR4FFAR1
SCHEMBL2350939 0.87 FFAR4 (0.61) FFAR4FFAR1AKR1C3
SCHEMBL2354861 0.86 FFAR4 (0.60) FFAR4FFAR1APPAKR1C3
SCHEMBL2349293 0.86 FFAR4 (0.60) FFAR4FFAR1
SCHEMBL9167497 0.86 FFAR1 (0.56) FFAR4FFAR1APP
SCHEMBL2351135 0.85 FFAR4 (0.62) FFAR4FFAR1AKR1C3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8008525-B2 For the 14273 peroxisome proliferator activated receptor; antidiabetic agents, hyperlipidemia, obesity or anorexia; receptor binding assay; drug screening kits TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2011-08-30 US disclosed
US-20080167378-A1 Receptor Function Regulation Agent TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2008-07-10 US disclosed
EP-1688138-A1 RECEPTOR FUNCTION REGULATING AGENT Takeda Pharmaceutical Company Limited (JP) 2006-08-09 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080167378-A1 Receptor Function Regulation Agent GPR119, INSR, GPR88 FFAR4 17/4885FFAR1 16/4885APP 4216/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.