SCHEMBL235410

SCHEMBL235410

N#Cc1ccc(C(=S)SSC(=S)c2ccc(C#N)cc2)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA2 P00918 3/20 0.48
CA1 P00915 2/20 0.48
CA12 O43570 1/20 0.46
CA3 P07451 1/20 0.46
CA6 P23280 1/20 0.46
CA9 Q16790 1/20 0.46
CA14 Q9ULX7 1/20 0.46
GSK3B P49841 2/20 0.44
MMP3 P08254 1/20 0.41
ENPP2 Q13822 1/20 0.41
IDO1 P14902 2/20 0.41
ALDH1A1 P00352 2/20 0.41
CYP2A6 P11509 2/20 0.41
PARP15 Q460N3 1/20 0.40
PARP10 Q53GL7 1/20 0.40
PARP2 Q9UGN5 1/20 0.40
MAOA P21397 3/20 0.39
MAOB P27338 3/20 0.39
TSHR P16473 1/20 0.39
MAPT P10636 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23600062 0.79 GSK3B (0.43) CA2CA1CA12CA3CA6
SCHEMBL4078022 0.78 CA2 (0.58) CA2CA1CA12CA3CA6
SCHEMBL233980 0.77 TTR (0.37) CA2CA1CA12CA3CA6
SCHEMBL16107022 0.77 CA2 (0.40) CA2CA1CA12CA3CA6
SCHEMBL9585491 0.76 CA2 (0.52) CA2CA1CA12CA3CA6
SCHEMBL2396144 0.74 CA2 (0.54) CA2CA1CA12CA3CA6
SCHEMBL2369004 0.74 CA2 (0.50) CA2CA1CA12CA3CA6
SCHEMBL16527195 0.74 CA2 (0.50) CA2CA1CA12CA3CA6
SCHEMBL7532498 0.74 CA2 (0.50) CA2CA1CA12CA3CA6
SCHEMBL7205889 0.74 CA2 (0.50) CA2CA1CA12CA3CA6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2544701-B1 POLYMERIC DRUG DELIVERY CONJUGATES AND METHODS OF MAKING AND USING THEREOF UNIV UTAH RES FOUND (US) 2019-08-14 EP disclosed
US-9745406-B2 Curable composition CEMEDINE CO., LTD. (JP) 2017-08-29 US disclosed
EP-2412756-B1 CURABLE COMPOSITION CEMEDINE CO LTD (JP) 2016-12-21 EP disclosed
US-9289510-B2 Polymeric drug delivery conjugates and methods of making and using thereof UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) 2016-03-22 US disclosed
EP-2812363-A2 PROCESS FOR THE TREATMENT OF A POLYMER Consiglio Nazionale Delle Ricerche (IT) 2014-12-17 EP disclosed
WO-2013118100-A2 PROCESS FOR THE TREATMENT OF A POLYMER CONSIGLIO NAZIONALE DELLE RICERCHE (IT) 2013-08-15 WO disclosed
US-20130156722-A1 POLYMERIC DRUG DELIVERY CONJUGATES AND METHODS OF MAKING AND USING THEREOF UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) 2013-06-20 US disclosed
EP-2544701-A2 POLYMERIC DRUG DELIVERY CONJUGATES AND METHODS OF MAKING AND USING THEREOF University of Utah Research Foundation (US) 2013-01-16 EP disclosed
EP-2412756-A1 CURABLE COMPOSITION CEMEDINE CO., LTD. (JP) 2012-02-01 EP disclosed
US-20120004371-A1 CURABLE COMPOSITION CEMEDINE CO., LTD. (JP) 2012-01-05 US disclosed
WO-2011112482-A2 POLYMERIC DRUG DELIVERY CONJUGATES AND METHODS OF MAKING AND USING THEREOF UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) 2011-09-15 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130156722-A1 POLYMERIC DRUG DELIVERY CONJUGATES AND METHODS OF MAKING AND USING THEREOF CD44, MMP7, MMP26 CA2 2646/4885CA1 617/4885CA12 152/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.