Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GOT1 | P17174 | 13/20 | 0.60 |
| ▸ | DRD2 | P14416 | 1/20 | 0.60 |
| ▸ | DRD4 | P21917 | 1/20 | 0.60 |
| ▸ | DRD3 | P35462 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2228008 | 0.80 | GOT1 (0.70) | GOT1DRD2DRD4DRD3GAA | |
| SCHEMBL31134492 | 0.80 | ALDH1A1 (0.51) | GAAMAPTTMEM97SIGMAR1MEN1 | |
| SCHEMBL2228656 | 0.80 | DRD2 (0.45) | DRD2DRD4DRD3TMEM97SIGMAR1 | |
| SCHEMBL1537795 | 0.79 | GAA (0.60) | GOT1GAAMAPTRECQL | |
| SCHEMBL30885791 | 0.79 | GAA (0.60) | GOT1GAAMAPTRECQL | |
| SCHEMBL2229131 | 0.78 | TMEM97 (0.47) | GAAMAPTTMEM97SIGMAR1MEN1 | |
| SCHEMBL31414573 | 0.78 | TMEM97 (0.47) | GAAMAPTTMEM97SIGMAR1MEN1 | |
| SCHEMBL5362589 | 0.78 | SMN1; SMN2 (0.72) | GAAMAPTTMEM97SIGMAR1MEN1 | |
| SCHEMBL31414524 | 0.77 | TMEM97 (0.46) | DRD2DRD3GAAMAPTTMEM97 | |
| SCHEMBL3970912 | 0.77 | MEN1 (0.76) | GAAMEN1KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011088838-A1 | NOVEL 6,6A,7,8,9,10-HEXAHYDRO-4H-4,8,10A-TRIAZA-ACEPHENANTHRYLENE DERIVATIVES AS DOPAMINE D2 LIGANDS | H. LUNDBECK A/S (DK) | 2011-07-28 | — | — | WO | disclosed |
| WO-2011088836-A1 | NOVEL 4-(ARYL-4-SULFONYL)-6,6a,7,8,9,10-HEXAHYDRO-4H-4,8,10a-TRIAZA-ACEPHENANTHRYLENE AND 3-ARYLSULFONYL-6,6a,7,8,9,10-HEXAHYDRO-3H-3,8,10a-TRIAZA-CYCLOPENTA[C]FLUORENE DERIVATIVES AS SEROTONIN 5-HT6 LIGANDS | H. LUNDBECK A/S (DK) | 2011-07-28 | — | — | WO | disclosed |