SCHEMBL23548003

SCHEMBL23548003

COC1C(O)[C@@H](CO)O[C@H]1n1c(C)nc2c(N)ncnc21

nearest known ligand 0.62

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
HSPA8 P11142 3/20 0.62
HSPA5 P11021 2/20 0.62
RXFP1 Q9HBX9 1/20 0.62
AMD1 P17707 3/20 0.61
RNASEL Q05823 1/20 0.58
HSD17B10 Q99714 1/20 0.58
GAPDH P04406 1/20 0.58
SLC28A2 O43868 3/20 0.56
LMNA P02545 1/20 0.54
TP53 P04637 1/20 0.54
HBB P68871 1/20 0.54
SMN1; SMN2 Q16637 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6388256 1.00 HSPA8 (0.62) HSPA8HSPA5RXFP1AMD1RNASEL
SCHEMBL28087475 1.00 HSPA8 (0.62) HSPA8HSPA5RXFP1AMD1RNASEL
SCHEMBL1737260 0.91 HSPA8 (0.76) HSPA8HSPA5RXFP1HSD17B10GAPDH
SCHEMBL30484790 0.90 HSPA8 (0.61) HSPA8HSPA5RXFP1HSD17B10GAPDH
SCHEMBL23547944 0.90 AMD1 (0.60) HSPA8HSPA5RXFP1AMD1RNASEL
SCHEMBL30237449 0.89 HSPA8 (0.60) HSPA8HSPA5RXFP1HSD17B10GAPDH
SCHEMBL1740341 0.89 NADK (0.61) HSPA8HSPA5RXFP1HSD17B10GAPDH
SCHEMBL5672368 0.89 HSPA8 (0.60) HSPA8HSPA5RXFP1HSD17B10GAPDH
SCHEMBL30237271 0.89 HSPA8 (0.60) HSPA8HSPA5RXFP1HSD17B10GAPDH
SCHEMBL5672193 0.89 NADK (0.61) HSPA8HSPA5RXFP1HSD17B10GAPDH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210189392-A1 S-ANTIGEN TRANSPORT INHIBITING OLIGONUCLEOTIDE POLYMERS AND METHODS ALIGOS THERAPEUTICS, INC. 2021-06-24 US disclosed