Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | GNAI3 | P08754 | 5/20 | 0.37 |
| ▸ | GNAO1 | P09471 | 5/20 | 0.37 |
| ▸ | GNAI1 | P63096 | 5/20 | 0.37 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.37 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26850073 | 0.93 | GNAO1 (0.42) | ALOX15GNAI3GNAO1GNAI1OPRL1 | |
| SCHEMBL24684743 | 0.93 | GNAO1 (0.42) | ALOX15GNAI3GNAO1GNAI1OPRL1 | |
| SCHEMBL16980461 | 0.89 | ALOX15 (0.35) | ALOX15GNAI3GNAO1GNAI1PIM1 | |
| SCHEMBL23696232 | 0.84 | GNAI3 (0.40) | ALOX15GNAI3GNAO1GNAI1 | |
| SCHEMBL26494066 | 0.84 | GNAO1 (0.44) | GNAI3GNAO1GNAI1 | |
| SCHEMBL21106055 | 0.83 | GNAI3 (0.36) | ALOX15GNAI3GNAO1GNAI1 | |
| SCHEMBL24023549 | 0.81 | ALOX15 (0.38) | ALOX15HTR4PIM1 | |
| SCHEMBL23696428 | 0.80 | GNAI3 (0.34) | ALOX15GNAI3GNAO1GNAI1 | |
| SCHEMBL1615678 | 0.80 | GNAO1 (0.50) | GNAI3GNAO1GNAI1OPRL1 | |
| SCHEMBL26843896 | 0.80 | GNAO1 (0.40) | GNAI3GNAO1GNAI1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022133480-A1 | ARYL HYDROCARBON RECEPTOR (AHR) AGONISTS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-23 | — | — | WO | disclosed |
| WO-2021127302-A1 | 2-(1H-INDOLE-3-CARBONYL)-THIAZOLE-4-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ARYL HYDROCARBON RECEPTOR (AHR) AGONISTS FOR THE TREATMENT OF E.G. ANGIOGENESIS IMPLICATED OR INFLAMMATORY DISORDERS | Ikena Oncology, Inc. (US) | 2021-06-24 | — | — | WO | disclosed |