Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 3/20 | 0.41 |
| ▸ | DRD2 | P14416 | 5/20 | 0.39 |
| ▸ | DRD4 | P21917 | 4/20 | 0.39 |
| ▸ | DRD3 | P35462 | 3/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | CCR2 | P41597 | 2/20 | 0.37 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23551374 | 0.87 | NAMPT (0.37) | CCR1DRD2DRD4DRD3CCR2 | |
| SCHEMBL23551470 | 0.86 | CCR1 (0.43) | CCR1CCR2SLC18A3NPC1 | |
| SCHEMBL23551428 | 0.84 | DGAT1 (0.40) | ALDH1A1 | |
| SCHEMBL23551340 | 0.82 | JAK2 (0.43) | DRD2DRD4DRD3JAK2SYK | |
| SCHEMBL24491308 | 0.69 | KDM1A (0.42) | ALDH1A1 | |
| SCHEMBL24125721 | 0.68 | DRD4 (0.54) | DRD4 | |
| SCHEMBL7202138 | 0.68 | SLC18A3 (0.62) | DRD2DRD4DRD3SLC18A3ALDH1A1 | |
| SCHEMBL15652766 | 0.67 | SLC18A3 (0.48) | DRD2DRD4DRD3JAK2SYK | |
| SCHEMBL23816922 | 0.66 | SLC18A3 (0.60) | DRD2DRD4DRD3SLC18A3ALDH1A1 | |
| SCHEMBL26162034 | 0.66 | JAK2 (0.42) | DRD2DRD4DRD3JAK2SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127561-A1 | ISOINDOLINONE AND INDAZOLE COMPOUNDS FOR THE DEGRADATION OF EGFR | C4 THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |