Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | CCR1 | P32246 | 3/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 4/20 | 0.35 |
| ▸ | DRD2 | P14416 | 3/20 | 0.35 |
| ▸ | DRD3 | P35462 | 3/20 | 0.35 |
| ▸ | CCR2 | P41597 | 2/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | WNT1 | P04628 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.33 |
| ▸ | FPR2 | P25090 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23551789 | 0.87 | CCR1 (0.41) | CCR1DRD4DRD2DRD3CCR2 | |
| SCHEMBL23551470 | 0.81 | CCR1 (0.43) | NAMPTCCR1CCR2EGFRLCK | |
| SCHEMBL23551428 | 0.76 | DGAT1 (0.40) | — | |
| SCHEMBL23551305 | 0.72 | DRD4 (0.41) | NAMPTDRD4DRD2DRD3CDK9 | |
| SCHEMBL21427098 | 0.72 | ALDH1A1 (0.42) | NAMPTDRD4DRD2DRD3CDK9 | |
| SCHEMBL27262583 | 0.71 | NAMPT (0.52) | NAMPTJAK1LCKJAK3 | |
| SCHEMBL21410102 | 0.70 | LTA4H (0.42) | NAMPTDRD4DRD2DRD3CDK9 | |
| SCHEMBL23551340 | 0.70 | JAK2 (0.43) | DRD4DRD2DRD3JAK3 | |
| SCHEMBL24125665 | 0.68 | CDK9 (0.35) | NAMPTDRD4DRD2DRD3CCR2 | |
| SCHEMBL23301205 | 0.68 | DDB1 (0.57) | HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127561-A1 | ISOINDOLINONE AND INDAZOLE COMPOUNDS FOR THE DEGRADATION OF EGFR | C4 THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |