Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 6/20 | 0.43 |
| ▸ | NAMPT | P43490 | 3/20 | 0.39 |
| ▸ | LCK | P06239 | 3/20 | 0.37 |
| ▸ | JAK3 | P52333 | 3/20 | 0.37 |
| ▸ | EGFR | P00533 | 2/20 | 0.37 |
| ▸ | UBE2M | P61081 | 1/20 | 0.36 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | STAT1 | P42224 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CCR2 | P41597 | 2/20 | 0.35 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23551789 | 0.86 | CCR1 (0.41) | CCR1NPC1CCR2SLC18A3 | |
| SCHEMBL23551428 | 0.83 | DGAT1 (0.40) | MAPT | |
| SCHEMBL23551374 | 0.81 | NAMPT (0.37) | CCR1NAMPTLCKJAK3EGFR | |
| SCHEMBL24491308 | 0.71 | KDM1A (0.42) | NAMPTJAK3 | |
| SCHEMBL23551340 | 0.68 | JAK2 (0.43) | JAK3NPC1 | |
| SCHEMBL24207418 | 0.66 | CTSL (0.40) | NAMPTSLC18A3 | |
| SCHEMBL28818445 | 0.65 | ESR2 (0.55) | — | |
| SCHEMBL16994794 | 0.65 | SLC18A3 (0.49) | MAPTNPC1RAB9ASMN1; SMN2SLC18A3 | |
| SCHEMBL23551763 | 0.65 | NAMPT (0.40) | NAMPTJAK3 | |
| SCHEMBL7854565 | 0.65 | SIGMAR1 (0.51) | NAMPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127561-A1 | ISOINDOLINONE AND INDAZOLE COMPOUNDS FOR THE DEGRADATION OF EGFR | C4 THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |