SCHEMBL23553003

SCHEMBL23553003

NCC1CCC(C(=O)NC(Cc2ccc3ccccc3c2)C(=O)NCCCCC(NC(=O)NC(CCC(=O)O)C(=O)O)C(=O)O)CC1

nearest known ligand 0.76

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ FOLH1 Q04609 13/20 0.76
▸ PLG P00747 7/20 0.62
▸ PRSS1 P07477 7/20 0.62
▸ PRSS2 P07478 7/20 0.62
▸ PRSS3 P35030 7/20 0.62
▸ PLAU P00749 2/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29679057 1.00 FOLH1 (0.76) FOLH1PLGPRSS1PRSS2PRSS3
SCHEMBL29679477 1.00 FOLH1 (0.76) FOLH1PLGPRSS1PRSS2PRSS3
SCHEMBL26090338 1.00 FOLH1 (0.76) FOLH1PLGPRSS1PRSS2PRSS3
SCHEMBL28659047 1.00 FOLH1 (0.76) FOLH1PLGPRSS1PRSS2PRSS3
SCHEMBL22883093 0.93 FOLH1 (0.75) FOLH1PLGPRSS1PRSS2PRSS3
SCHEMBL19296397 0.92 FOLH1 (0.76) FOLH1PLGPRSS1PRSS2PRSS3
SCHEMBL27303660 0.92 FOLH1 (0.73) FOLH1PLGPRSS1PRSS2PRSS3
SCHEMBL26178698 0.92 FOLH1 (0.78) FOLH1PLGPRSS1PRSS2PRSS3
SCHEMBL26001462 0.92 FOLH1 (0.78) FOLH1PLGPRSS1PRSS2PRSS3
SCHEMBL22883091 0.91 FOLH1 (0.72) FOLH1PLGPRSS1PRSS2PRSS3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250222143-A1 TARGETED RADIOTHERANOSTICS BASED ON POLYAZAMACROCYCLIC, MIXED-DONOR SCAFFOLDS LINKED TO A TARGETING VECTOR THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) 2025-07-10 — — US claimed
WO-2023070004-A1 TARGETED RADIOTHERANOSTICS BASED ON POLYAZAMACROCYCLIC, MIXED-DONOR SCAFFOLDS LINKED TO A TARGETING VECTOR THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) 2023-04-27 — — WO claimed
US-20250222143-A1 TARGETED RADIOTHERANOSTICS BASED ON POLYAZAMACROCYCLIC, MIXED-DONOR SCAFFOLDS LINKED TO A TARGETING VECTOR THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) 2025-07-10 — — US disclosed
WO-2023070004-A1 TARGETED RADIOTHERANOSTICS BASED ON POLYAZAMACROCYCLIC, MIXED-DONOR SCAFFOLDS LINKED TO A TARGETING VECTOR THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) 2023-04-27 — — WO disclosed
WO-2023070004-A1 TARGETED RADIOTHERANOSTICS BASED ON POLYAZAMACROCYCLIC, MIXED-DONOR SCAFFOLDS LINKED TO A TARGETING VECTOR THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) 2023-04-27 — — WO disclosed
US-11547767-B2 99mTc-EDDA/HYNIC-iPSMA as a radiopharmaceutical for detecting the overexpression of prostate-specific membrane antigen INSTITUTO NACIONAL DE INVESTIGACIONES NUCLEARES (MX) 2023-01-10 — — US disclosed
CN-113747927-A Prostate Specific Membrane Antigen (PSMA) ligands comprising an amylase cleavable linker 德国癌症研究中心 2021-12-03 — — CN disclosed
US-20210187132-A1 99MTC-EDDA/HYNIC-IPSMA AS A RADIOPHARMACEUTICAL FOR DETECTING THE OVEREXPRESSION OF PROSTATE-SPECIFIC MEMBRANE ANTIGEN INSTITUTO NACIONAL DE INVESTIGACIONES NUCLEARES (MX) 2021-06-24 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210187132-A1 99MTC-EDDA/HYNIC-IPSMA AS A RADIOPHARMACEUTICAL FOR DETECTING THE OVEREXPRESSION OF PROSTATE-SPECIFIC MEMBRANE ANTIGEN KLK3, EPS15, CD99 FOLH1 21/4885PLG 3524/4885PRSS1 1265/4885
US-20250222143-A1 TARGETED RADIOTHERANOSTICS BASED ON POLYAZAMACROCYCLIC, MIXED-DONOR SCAFFOLDS LINKED TO A TARGETING VECTOR PAICS, RABGGTB, PARP1 FOLH1 138/4885PLG 3803/4885PRSS1 2512/4885
US-11547767-B2 99mTc-EDDA/HYNIC-iPSMA as a radiopharmaceutical for detecting the overexpression of prostate-specific membrane antigen KLK3, EPS15, CD99 FOLH1 21/4885PLG 3524/4885PRSS1 1265/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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