Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.49 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13072040 | 0.83 | TSHR (0.49) | KDM4ETSHRALDH1A1MEN1KMT2A | |
| SCHEMBL14860417 | 0.83 | TSHR (0.49) | KDM4ETSHRALDH1A1ATMMEN1 | |
| SCHEMBL609984 | 0.83 | KDM4E (0.54) | KDM4ETSHRALDH1A1ALOX15RAB9A | |
| SCHEMBL14686821 | 0.82 | NPC1 (0.54) | KDM4ETSHRALDH1A1RAB9ANPC1 | |
| SCHEMBL5664007 | 0.82 | KDM4E (0.57) | KDM4ETSHRALDH1A1ALOX15RAB9A | |
| SCHEMBL1017506 | 0.81 | KDM4E (0.55) | KDM4ETSHRALDH1A1ALOX15RAB9A | |
| SCHEMBL4192112 | 0.81 | CYP1A2 (0.62) | KDM4ETSHRALDH1A1ALOX15RAB9A | |
| SCHEMBL14686577 | 0.79 | GABRP (0.61) | KDM4ETSHRALDH1A1ALOX15RAB9A | |
| Hydrochloric Acid SCHEMBL30639526 | 0.79 | KDM4E (0.54) | KDM4ETSHRALDH1A1ALOX15RAB9A | |
| SCHEMBL15211304 | 0.79 | KDM4E (0.54) | KDM4ETSHRALDH1A1ALOX15RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109293567-A | A kind of synthetic method of the bromo- 2- methylnicotinic acid ethyl ester of 5- | 上海睿腾医药科技有限公司 | 2019-02-01 | — | — | CN | claimed |
| EP-3689868-B1 | TETRAHYDRONAPHTHALENE AND TETRAHYDROISOQUINOLINE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS | ARVINAS OPERATIONS INC (US) | 2023-09-27 | — | — | EP | disclosed |
| EP-3689868-A1 | TETRAHYDRONAPHTHALENE AND TETRAHYDROISOQUINOLINE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS | Arvinas Operations, Inc. (US) | 2020-08-05 | — | — | EP | disclosed |
| CN-110520423-A | AMINOTRIAZOLOPYRIDINES AS KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO | 2019-11-29 | — | — | CN | disclosed |
| CN-107108637-B | Triazolopyrimidine compound and application thereof | NOVARTIS AG (CH) | 2019-10-29 | — | — | CN | disclosed |
| CN-109790166-A | imidazopyridine compounds for the treatment of cancer | 诺华股份有限公司 | 2019-05-21 | — | — | CN | disclosed |
| CN-109293567-A | A kind of synthetic method of the bromo- 2- methylnicotinic acid ethyl ester of 5- | 上海睿腾医药科技有限公司 | 2019-02-01 | — | — | CN | disclosed |
| CN-109293567-A | A kind of synthetic method of the bromo- 2- methylnicotinic acid ethyl ester of 5- | 上海睿腾医药科技有限公司 | 2019-02-01 | — | — | CN | disclosed |
| CN-109293567-A | A kind of synthetic method of the bromo- 2- methylnicotinic acid ethyl ester of 5- | 上海睿腾医药科技有限公司 | 2019-02-01 | — | — | CN | disclosed |
| WO-2018102725-A1 | TETRAHYDRONAPHTHALENE AND TETRAHYDROISOQUINOLINE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS | Arvinas, Inc. (US) | 2018-06-07 | — | — | WO | disclosed |
| US-20140343049-A1 | DIHYDROFURAN DERIVATIVES AS INSECTICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2014-11-20 | — | — | US | disclosed |
| US-20130096144-A1 | ISOINDOLINONE AND PYRROLOPYRIDINONE DERIVATIVES AS AKT INHIBITORS | INCYTE CORPORATION (US) | 2013-04-18 | — | — | US | disclosed |
| WO-2013056015-A1 | ISOINDOLINONE AND PYRROLOPYRIDINONE DERIVATIVES AS AKT INHIBITORS | INCYTE CORPORATION (US) | 2013-04-18 | — | — | WO | disclosed |
| WO-2013056015-A1 | ISOINDOLINONE AND PYRROLOPYRIDINONE DERIVATIVES AS AKT INHIBITORS | INCYTE CORPORATION (US) | 2013-04-18 | — | — | WO | disclosed |
| US-20130096144-A1 | ISOINDOLINONE AND PYRROLOPYRIDINONE DERIVATIVES AS AKT INHIBITORS | INCYTE CORPORATION (US) | 2013-04-18 | — | — | US | disclosed |
| US-20130096144-A1 | ISOINDOLINONE AND PYRROLOPYRIDINONE DERIVATIVES AS AKT INHIBITORS | INCYTE CORPORATION (US) | 2013-04-18 | — | — | US | disclosed |
| WO-2013026724-A1 | DIHYDROFURAN DERIVATIVES AS INSECTICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2013-02-28 | — | — | WO | disclosed |
| EP-2539330-A1 | DIHYDROFURAN DERIVATIVES AS INSECTICIDAL COMPOUNDS | Syngenta Participations AG (CH) | 2013-01-02 | — | — | EP | disclosed |
| US-20120329769-A1 | DIHYDROFURAN DERIVATIVES AS INSECTICIDAL COMPOUNDS | SYNGENTA CROP PROTECTION LLC (US) | 2012-12-27 | — | — | US | disclosed |
| WO-2011101229-A1 | DIHYDROFURAN DERIVATIVES AS INSECTICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2011-08-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120329769-A1 | DIHYDROFURAN DERIVATIVES AS INSECTICIDAL COMPOUNDS | FOXM1, NDUFC1, H1-0 | KDM4E 1915/4885TSHR 4255/4885ALDH1A1 93/4885 |
| US-20130096144-A1 | ISOINDOLINONE AND PYRROLOPYRIDINONE DERIVATIVES AS AKT INHIBITORS | MTOR, PDPK1, PIK3CA | KDM4E 2332/4885TSHR 4065/4885ALDH1A1 3634/4885 |
| US-20140343049-A1 | DIHYDROFURAN DERIVATIVES AS INSECTICIDAL COMPOUNDS | NQO2, NIT2, QDPR | KDM4E 1563/4885TSHR 4664/4885ALDH1A1 73/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.