Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | PTPRB | P23467 | 1/20 | 0.41 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.41 |
| ▸ | CFTR | P13569 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.38 |
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30299290 | 0.88 | MAPT (0.45) | MAPTMAPK1PTPRBUCHL1CFTR | |
| SCHEMBL23539332 | 0.85 | ALDH1A1 (0.42) | MAPTMAPK1PTPRBUCHL1CFTR | |
| SCHEMBL30299297 | 0.85 | ALDH1A1 (0.42) | MAPTMAPK1PTPRBUCHL1CFTR | |
| SCHEMBL30299326 | 0.84 | UCHL1 (0.43) | MAPTMAPK1PTPRBUCHL1CFTR | |
| SCHEMBL23554133 | 0.84 | UCHL1 (0.43) | MAPTMAPK1PTPRBUCHL1CFTR | |
| SCHEMBL23554241 | 0.84 | GRM1 (0.45) | MAPTMAPK1PTPRBUCHL1KDM4E | |
| SCHEMBL23553756 | 0.83 | HDAC3 (0.42) | MAPTMAPK1PTPRBUCHL1CFTR | |
| SCHEMBL23553654 | 0.82 | MEN1 (0.44) | MAPTUCHL1MEN1ALDH1A1KMT2A | |
| SCHEMBL23554141 | 0.82 | UCHL1 (0.37) | MAPTMAPK1PTPRBUCHL1CFTR | |
| SCHEMBL23554142 | 0.81 | GSTO1 (0.38) | MAPTMAPK1PTPRBUCHL1CFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127301-A1 | 4-PHENYL-N-(PHENYL)THIAZOL-2-AMINE DERIVATIVES AND RELATED COMPOUNDS AS ARYL HYDROCARBON RECEPTOR (AHR) AGONISTS FOR THE TREATMENT OF E.G. ANGIOGENESIS IMPLICATED OR INFLAMMATORY DISORDERS | Ikena Oncology, Inc. (US) | 2021-06-24 | — | — | WO | disclosed |