Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 12/20 | 0.49 |
| ▸ | RARB | P10826 | 9/20 | 0.49 |
| ▸ | RARG | P13631 | 9/20 | 0.49 |
| ▸ | CYP26A1 | O43174 | 5/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | CYP26B1 | Q9NR63 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.42 |
| ▸ | BLVRB | P30043 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2179109 | 0.91 | RARA (0.53) | RARARARBRARGCYP26A1CYP3A4 | |
| SCHEMBL2179107 | 0.91 | RARA (0.53) | RARARARBRARGCYP26A1CYP3A4 | |
| SCHEMBL2180255 | 0.86 | LMNA (0.51) | MEN1KMT2ALMNATP53ADORA3 | |
| SCHEMBL2180708 | 0.85 | GAA (0.48) | CYP3A4MEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL2180613 | 0.85 | LMNA (0.44) | LMNATP53ITGB3ITGA2BITGA2 | |
| SCHEMBL2180687 | 0.84 | PLAU (0.52) | MEN1KMT2ALMNATP53ITGB3 | |
| SCHEMBL2182460 | 0.84 | LMNA (0.52) | MAPK1LMNATP53PGRADORA3 | |
| SCHEMBL2178443 | 0.83 | LMNA (0.44) | MEN1KMT2AALDH1A1TSHRMAPK1 | |
| SCHEMBL2181321 | 0.83 | ABCB1 (0.45) | LMNATP53ITGB3ITGA2BITGA2 | |
| SCHEMBL2180319 | 0.82 | MAPT (0.47) | MEN1KMT2AALDH1A1TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519500-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | Piramal Healthcare Ltd. (IN) | 2012-11-07 | — | — | EP | disclosed |
| WO-2011080718-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2011-07-07 | — | — | WO | disclosed |