Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 7/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | THRB | P10828 | 2/20 | 0.43 |
| ▸ | NOS3 | P29474 | 2/20 | 0.43 |
| ▸ | NOS1 | P29475 | 2/20 | 0.43 |
| ▸ | NOS2 | P35228 | 2/20 | 0.43 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21887188 | 0.92 | BCL2 (0.54) | BCL2ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL17707286 | 0.81 | SIGMAR1 (0.50) | NOS1NOS2SIGMAR1GRIN2DGRIN3B | |
| SCHEMBL17707285 | 0.81 | SIGMAR1 (0.50) | NOS1NOS2SIGMAR1GRIN2DGRIN3B | |
| SCHEMBL21887190 | 0.80 | RAB9A (0.49) | ALDH1A1MAPTMEN1KMT2APOLB | |
| SCHEMBL46935 | 0.76 | BCL2 (0.66) | BCL2ALDH1A1RAB9APKMSMN1; SMN2 | |
| SCHEMBL30394310 | 0.76 | BCL2 (0.66) | BCL2ALDH1A1RAB9APKMSMN1; SMN2 | |
| SCHEMBL28424644 | 0.76 | CCNE2 (0.50) | ALDH1A1MAPTMEN1KMT2APOLB | |
| SCHEMBL28424645 | 0.76 | CCNE2 (0.50) | ALDH1A1MAPTMEN1KMT2APOLB | |
| SCHEMBL31045928 | 0.75 | RAB9A (0.65) | ALDH1A1MAPTMEN1KMT2APOLB | |
| SCHEMBL69865 | 0.75 | RAB9A (0.65) | ALDH1A1MAPTMEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127301-A1 | 4-PHENYL-N-(PHENYL)THIAZOL-2-AMINE DERIVATIVES AND RELATED COMPOUNDS AS ARYL HYDROCARBON RECEPTOR (AHR) AGONISTS FOR THE TREATMENT OF E.G. ANGIOGENESIS IMPLICATED OR INFLAMMATORY DISORDERS | Ikena Oncology, Inc. (US) | 2021-06-24 | — | — | WO | disclosed |