Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKN1 | Q16512 | 1/20 | 0.68 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.68 |
| ▸ | CSNK1A1 | P48729 | 7/20 | 0.64 |
| ▸ | CSNK1D | P48730 | 7/20 | 0.64 |
| ▸ | CSNK1G2 | P78368 | 6/20 | 0.64 |
| ▸ | GSK3B | P49841 | 5/20 | 0.64 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.63 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.61 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.61 |
| ▸ | RHEB | Q15382 | 1/20 | 0.60 |
| ▸ | METAP2 | P50579 | 1/20 | 0.53 |
| ▸ | METAP1 | P53582 | 1/20 | 0.53 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.49 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.48 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.48 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20982510 | 0.90 | PKN1 (0.82) | PKN1PKN2CSNK1A1CSNK1DCSNK1G2 | |
| SCHEMBL3341423 | 0.83 | PKN1 (0.72) | PKN1PKN2CSNK1A1CSNK1DCSNK1G2 | |
| SCHEMBL14816640 | 0.83 | PKN1 (0.72) | PKN1PKN2CSNK1A1CSNK1DCSNK1G2 | |
| SCHEMBL18764054 | 0.82 | CHEK2 (0.78) | PKN1PKN2CSNK1A1CSNK1DCSNK1G2 | |
| SCHEMBL1662880 | 0.80 | MEN1 (0.77) | PKN1PKN2CHEK2DGAT1SOAT1 | |
| SCHEMBL23999350 | 0.79 | KDR (0.59) | PKN1PKN2CSNK1A1CSNK1DCSNK1G2 | |
| SCHEMBL31592829 | 0.79 | CSNK1A1 (0.53) | PKN1PKN2CSNK1A1CSNK1DCSNK1G2 | |
| SCHEMBL23999436 | 0.79 | KDR (0.59) | PKN1PKN2CSNK1A1CSNK1DCSNK1G2 | |
| SCHEMBL6061287 | 0.78 | PKN1 (0.65) | PKN1PKN2CSNK1A1CSNK1DCSNK1G2 | |
| SCHEMBL31593002 | 0.78 | DGAT1 (0.72) | CSNK1A1CSNK1DCSNK1G2GSK3BDGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230054976-A1 | METHODS FOR INHIBITION OF ALPHA-SYNUCLEIN mRNA USING SMALL MOLECULES | UNIVERSITY OF FLORIDA BOARD OF TRUSTEES | 2023-02-23 | — | — | US | disclosed |
| WO-2021127367-A9 | METHODS FOR INHIBITION OF ALPHA-SYNUCLEIN mRNA USING SMALL MOLECULES | THE SCRIPPS RESEARCH INSTITUTE (US) | 2022-03-17 | — | — | WO | disclosed |
| WO-2021127367-A2 | METHODS FOR INHIBITION OF ALPHA-SYNUCLEIN mRNA USING SMALL MOLECULES | THE SCRIPPS RESEARCH INSTITUTE (US) | 2021-06-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230054976-A1 | METHODS FOR INHIBITION OF ALPHA-SYNUCLEIN mRNA USING SMALL MOLECULES | SNCA, EIF2AK2, LRRK2 | PKN1 1879/4885PKN2 600/4885CSNK1A1 1159/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.