Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKN1 | Q16512 | 1/20 | 0.65 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.65 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.60 |
| ▸ | METAP2 | P50579 | 1/20 | 0.57 |
| ▸ | METAP1 | P53582 | 1/20 | 0.57 |
| ▸ | DGAT1 | O75907 | 4/20 | 0.56 |
| ▸ | ATR | Q13535 | 2/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.55 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.55 |
| ▸ | RHEB | Q15382 | 1/20 | 0.54 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.53 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.46 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.46 |
| ▸ | GSK3B | P49841 | 2/20 | 0.46 |
| ▸ | CSNK1G2 | P78368 | 2/20 | 0.46 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.46 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6507881 | 0.90 | RHEB (0.54) | PKN1PKN2CHEK2METAP2METAP1 | |
| SCHEMBL20982510 | 0.87 | PKN1 (0.82) | PKN1PKN2CHEK2METAP2METAP1 | |
| SCHEMBL3341423 | 0.81 | PKN1 (0.72) | PKN1PKN2CHEK2METAP2METAP1 | |
| SCHEMBL14816640 | 0.81 | PKN1 (0.72) | PKN1PKN2CHEK2METAP2METAP1 | |
| SCHEMBL15245229 | 0.81 | DGAT1 (0.53) | PKN1PKN2CHEK2METAP2METAP1 | |
| SCHEMBL18764054 | 0.80 | CHEK2 (0.78) | PKN1PKN2CHEK2METAP2METAP1 | |
| SCHEMBL6061570 | 0.79 | METAP2 (0.45) | PKN1PKN2CHEK2METAP2METAP1 | |
| SCHEMBL23563056 | 0.78 | PKN1 (0.68) | PKN1PKN2CHEK2METAP2METAP1 | |
| SCHEMBL5428774 | 0.77 | METAP2 (0.66) | PKN1PKN2CHEK2METAP2METAP1 | |
| SCHEMBL903006 | 0.76 | METAP2 (0.61) | PKN1PKN2CHEK2METAP2METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682518-A1 | DICATIONIC TRIARYL ANALOGS AS ANTI-PROTOZOAN AGENTS | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005040132-A1 | DICATIONIC TRIARYL ANALOGS AS ANTI-PROTOZOAN AGENTS | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2005-05-06 | — | — | WO | disclosed |