Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 12/20 | 0.40 |
| ▸ | SPHK2 | Q9NRA0 | 7/20 | 0.35 |
| ▸ | APLNR | P35414 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11075962 | 0.90 | CYP2C9 (0.43) | SPHK1APLNR | |
| SCHEMBL11075966 | 0.90 | CYP2C9 (0.43) | SPHK1APLNR | |
| SCHEMBL11066467 | 0.88 | MEN1 (0.42) | SPHK1SPHK2 | |
| SCHEMBL11066471 | 0.88 | MEN1 (0.42) | SPHK1SPHK2 | |
| SCHEMBL26800843 | 0.88 | SPHK1 (0.35) | SPHK1 | |
| SCHEMBL11073335 | 0.87 | MAPT (0.41) | SPHK1SPHK2 | |
| SCHEMBL11073336 | 0.87 | MAPT (0.41) | SPHK1SPHK2 | |
| SCHEMBL11073489 | 0.86 | SPHK1 (0.41) | SPHK1SPHK2 | |
| SCHEMBL11073487 | 0.86 | SPHK1 (0.41) | SPHK1SPHK2 | |
| SCHEMBL11067229 | 0.85 | SPHK1 (0.40) | SPHK1SPHK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210188845-A1 | SUBSTITUTED BICYCLIC COMPOUNDS USEFUL AS T CELL ACTIVATORS | BRISTOL-MYERS SQUIBB COMPANY | 2021-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210188845-A1 | SUBSTITUTED BICYCLIC COMPOUNDS USEFUL AS T CELL ACTIVATORS | DGKA, DGKZ, DGKK | SPHK1 258/4885SPHK2 326/4885APLNR 2259/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.