Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 16/20 | 0.81 |
| ▸ | EDNRA | P25101 | 16/20 | 0.81 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.81 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.81 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.81 |
| ▸ | POLB | P06746 | 1/20 | 0.81 |
| ▸ | IL36G | Q9NZH8 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2352546 | 1.00 | EDNRB (0.81) | EDNRBEDNRANR1I2KCNE1KCNQ1 | |
| SCHEMBL15991881 | 0.90 | EDNRB (0.77) | EDNRBEDNRANR1I2KCNE1KCNQ1 | |
| SCHEMBL10316295 | 0.90 | EDNRB (0.70) | EDNRBEDNRANR1I2KCNE1KCNQ1 | |
| SCHEMBL10316292 | 0.90 | EDNRB (0.66) | EDNRBEDNRANR1I2KCNE1KCNQ1 | |
| Ambrisentan SCHEMBL3679 | 0.90 | EDNRB (1.00) | EDNRBEDNRANR1I2KCNE1KCNQ1 | |
| Ambrisentan SCHEMBL3023434 | 0.90 | EDNRB (1.00) | EDNRBEDNRANR1I2KCNE1KCNQ1 | |
| Ambrisentan SCHEMBL20769813 | 0.90 | EDNRB (1.00) | EDNRBEDNRANR1I2KCNE1KCNQ1 | |
| Ambrisentan SCHEMBL138157 | 0.90 | EDNRB (1.00) | EDNRBEDNRANR1I2KCNE1KCNQ1 | |
| SCHEMBL3714105 | 0.87 | EDNRB (0.72) | EDNRBEDNRANR1I2KCNE1KCNQ1 | |
| SCHEMBL3714106 | 0.87 | EDNRB (0.72) | EDNRBEDNRANR1I2KCNE1KCNQ1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8404840-B2 | Process for the preparation of endothelin receptor antagonists | MSN LABORATORIES LIMITED (IL) | 2013-03-26 | — | — | US | claimed |
| US-20110263854-A1 | Improved Process For The Preparation Of Endothelin Receptor Antagonists | MSN LABORATORIES LIMITED (IN) | 2011-10-27 | — | — | US | claimed |
| EP-2350024-A2 | IMPROVED PROCESS FOR THE PREPARATION OF ENDOTHELIN RECEPTOR ANTAGONISTS | MSN Laboratories Limited (IN) | 2011-08-03 | — | — | EP | claimed |
| WO-2010070658-A2 | IMPROVED PROCESS FOR THE PREPARATION OF ENDOTHELIN RECEPTOR ANTAGONISTS | MSN LABORATORIES LIMITED (IN) | 2010-06-24 | — | — | WO | claimed |
| CN-110437063-B | Preparation method of ambrisentan key intermediate | 常州恒邦药业有限公司 | 2022-04-29 | — | — | CN | disclosed |
| US-9040698-B2 | Method for preparing optically pure (+)-ambrisentan and (+)-darusentan | INSTITUTE OF CHEMISTRY CHINESE ACADEMY OF SCIENCES (CN) | 2015-05-26 | — | — | US | disclosed |
| US-20140256004-A1 | Process for the Preparation of an Endothelin Receptor Antagonist | CIPLA LIMITED (IN) | 2014-09-11 | — | — | US | disclosed |
| US-20140249309-A1 | Method for Preparing Optically Pure (+)-Ambrisentan and (+)-Darusentan | INSTITUTE OF CHEMISTRY CHINESE ACADEMY OF SCIENCES (CN) | 2014-09-04 | — | — | US | disclosed |
| EP-2768811-A1 | PROCESS FOR THE PREPARATION OF AN ENDOTHELIN RECEPTOR ANTAGONIST | Cipla Limited (IN) | 2014-08-27 | — | — | EP | disclosed |
| WO-2013057468-A1 | PROCESS FOR THE PREPARATION OF AN ENDOTHELIN RECEPTOR ANTAGONIST | CIPLA LIMITED (IN) | 2013-04-25 | — | — | WO | disclosed |
| US-8404840-B2 | Process for the preparation of endothelin receptor antagonists | MSN LABORATORIES LIMITED (IL) | 2013-03-26 | — | — | US | disclosed |
| US-8217155-B2 | Metabolites and derivatives of ambrisentan | GILEAD COLORADO, INC. (US) | 2012-07-10 | — | — | US | disclosed |
| US-20110263854-A1 | Improved Process For The Preparation Of Endothelin Receptor Antagonists | MSN LABORATORIES LIMITED (IN) | 2011-10-27 | — | — | US | disclosed |
| EP-2350024-A2 | IMPROVED PROCESS FOR THE PREPARATION OF ENDOTHELIN RECEPTOR ANTAGONISTS | MSN Laboratories Limited (IN) | 2011-08-03 | — | — | EP | disclosed |
| US-20100204163-A1 | METABOLITES AND DERIVATIVES OF AMBRISENTAN | GILEAD COLORADO, INC. (US) | 2010-08-12 | — | — | US | disclosed |
| US-20100204163-A1 | METABOLITES AND DERIVATIVES OF AMBRISENTAN | GILEAD COLORADO, INC. (US) | 2010-08-12 | — | — | US | disclosed |
| WO-2010070658-A2 | IMPROVED PROCESS FOR THE PREPARATION OF ENDOTHELIN RECEPTOR ANTAGONISTS | MSN LABORATORIES LIMITED (IN) | 2010-06-24 | — | — | WO | disclosed |
| US-20090069353-A1 | DEUTERIUM-ENRICHED AMBRISENTAN | PROTIA, LLC (US) | 2009-03-12 | — | — | US | disclosed |
| US-20090069353-A1 | DEUTERIUM-ENRICHED AMBRISENTAN | PROTIA, LLC (US) | 2009-03-12 | — | — | US | disclosed |
| WO-2009017777-A2 | METABOLITES AND DERIVATIVES OF AMBRISENTAN | GILEAD COLORADO, INC. (US) | 2009-02-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110263854-A1 | Improved Process For The Preparation Of Endothelin Receptor Antagonists | EDNRA, EDNRB, ECE1 | EDNRB 2/4885EDNRA 1/4885NR1I2 2109/4885 |
| US-20140256004-A1 | Process for the Preparation of an Endothelin Receptor Antagonist | EDNRB, EDNRA, AGTR1 | EDNRB 1/4885EDNRA 2/4885NR1I2 520/4885 |
| US-20140249309-A1 | Method for Preparing Optically Pure (+)-Ambrisentan and (+)-Darusentan | AKR1D1, AKR1C2, AKR1C1 | EDNRB 47/4885EDNRA 30/4885NR1I2 2176/4885 |
| US-20090069353-A1 | DEUTERIUM-ENRICHED AMBRISENTAN | AVPR2, MC2R, AVPR1A | EDNRB 104/4885EDNRA 73/4885NR1I2 2677/4885 |
| US-20100204163-A1 | METABOLITES AND DERIVATIVES OF AMBRISENTAN | EDNRA, UGT1A3, EDNRB | EDNRB 3/4885EDNRA 1/4885NR1I2 454/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.