Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKN1 | Q16512 | 1/20 | 0.56 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.56 |
| ▸ | METAP2 | P50579 | 1/20 | 0.52 |
| ▸ | METAP1 | P53582 | 1/20 | 0.52 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.52 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.49 |
| ▸ | HTR6 | P50406 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.47 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.44 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.44 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.44 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.44 |
| ▸ | GSK3B | P49841 | 2/20 | 0.44 |
| ▸ | CSNK1G2 | P78368 | 2/20 | 0.44 |
| ▸ | RHEB | Q15382 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.42 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23540669 | 0.91 | PKN1 (0.53) | PKN1PKN2METAP2METAP1MAP3K14 | |
| SCHEMBL23540667 | 0.82 | RHEB (0.48) | PKN1PKN2MAP3K14CHEK2HTR6 | |
| SCHEMBL13323651 | 0.79 | HTR6 (0.63) | MAP3K14HTR6SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL20982510 | 0.76 | PKN1 (0.82) | PKN1PKN2METAP2METAP1CHEK2 | |
| SCHEMBL14045549 | 0.76 | MAP3K14 (0.47) | MAP3K14HTR6SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL10082075 | 0.73 | MAP3K14 (0.50) | METAP2METAP1MAP3K14HTR6SLC6A4 | |
| SCHEMBL7382807 | 0.73 | FGFR1 (0.46) | — | |
| SCHEMBL18764054 | 0.73 | CHEK2 (0.78) | PKN1PKN2METAP2METAP1CHEK2 | |
| SCHEMBL11293385 | 0.73 | PKN1 (0.62) | PKN1PKN2METAP2METAP1CHEK2 | |
| SCHEMBL902863 | 0.72 | PKN1 (0.54) | PKN1PKN2METAP2METAP1CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127452-A1 | COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS AND POTENTIATION OF ANTIBIOTICS | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2021-06-24 | — | — | WO | disclosed |