Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 2/20 | 0.46 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | GUSB | P08236 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | NT5E | P21589 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MGAM | O43451 | 1/20 | 0.41 |
| ▸ | SI | P14410 | 1/20 | 0.41 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.41 |
| ▸ | TNKS | O95271 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7383662 | 0.79 | KDM4E (0.50) | FGFR1FGFR2MEN1KMT2AGUSB | |
| SCHEMBL7377174 | 0.78 | FGFR1 (0.48) | FGFR1FGFR2MEN1KMT2AGUSB | |
| SCHEMBL14883366 | 0.75 | TNKS (0.51) | FGFR1FGFR2MEN1KMT2AGUSB | |
| SCHEMBL23567193 | 0.73 | PKN1 (0.56) | — | |
| SCHEMBL14876864 | 0.72 | GUSB (0.54) | FGFR1FGFR2MEN1KMT2AGUSB | |
| SCHEMBL14877000 | 0.72 | GUSB (0.60) | FGFR1FGFR2GUSBKDM4EHPGD | |
| SCHEMBL28919729 | 0.72 | GUSB (0.60) | GUSBKDM4EHPGDCDK4TNKS | |
| SCHEMBL23540667 | 0.71 | RHEB (0.48) | NT5EGAAMGAMSIMGAM2 | |
| SCHEMBL18392181 | 0.71 | HTR6 (0.49) | CDK4GAAMGAMSIMGAM2 | |
| SCHEMBL8033955 | 0.71 | MEN1 (0.63) | FGFR1FGFR2MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0980374-A1 | PHOSPHODIESTERASE 4-INHIBITING DIAZEPINOINDOLONES | PARKE-DAVIS (FR) | 2000-02-23 | — | — | EP | claimed |
| WO-1998049169-A1 | PHOSPHODIESTERASE 4-INHIBITING DIAZEPINOINDOLONES | PARKE-DAVIS (FR) | 1998-11-05 | — | — | WO | claimed |