Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | LTA4H | P09960 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 2/20 | 0.48 |
| ▸ | CCR8 | P51685 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8551044 | 0.85 | MEN1 (0.59) | SMN1; SMN2NPC1RAB9ACCR8KDM4E | |
| Hydrochloric Acid SCHEMBL8550696 | 0.83 | MEN1 (0.58) | SMN1; SMN2NPC1RAB9ACCR8KDM4E | |
| SCHEMBL8173819 | 0.83 | SMN1; SMN2 (0.56) | SMN1; SMN2NPC1RAB9ACYP2C19LTA4H | |
| SCHEMBL27541183 | 0.83 | SMN1; SMN2 (0.46) | SMN1; SMN2NPC1RAB9ACYP2C19LTA4H | |
| SCHEMBL14845464 | 0.82 | HTR2A (0.64) | SMN1; SMN2NPC1RAB9ALTA4HEGFR | |
| SCHEMBL3361971 | 0.82 | EGFR (0.55) | SMN1; SMN2NPC1RAB9ACYP2C19LTA4H | |
| SCHEMBL26454342 | 0.81 | EGFR (0.59) | SMN1; SMN2NPC1RAB9ALTA4HEGFR | |
| SCHEMBL10917021 | 0.81 | FABP7 (0.58) | SMN1; SMN2NPC1RAB9ACYP2C19ALDH1A1 | |
| SCHEMBL6666657 | 0.81 | FABP7 (0.58) | SMN1; SMN2NPC1RAB9ACYP2C19ALDH1A1 | |
| SCHEMBL280126 | 0.81 | FABP7 (0.58) | SMN1; SMN2NPC1RAB9ACYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9611290-B2 | Trypsin-like serine protease inhibitors, and their preparation and use | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2017-04-04 | — | — | US | disclosed |
| EP-2528895-B1 | TRYPSIN-LIKE SERINE PROTEASE INHIBITORS, AND THEIR PREPARATION AND USE | MEDICINES CO LEIPZIG GMBH (DE) | 2016-03-30 | — | — | EP | disclosed |
| CN-102858744-B | trypsin-like serine protease inhibitor and preparation method and application thereof | MEDICINES CO LEIPZIG GMBH | 2015-03-04 | — | — | CN | disclosed |
| US-20140073573-A1 | TRYPSIN-LIKE SERINE PROTEASE INHIBITORS, AND THEIR PREPARATION AND USE | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2014-03-13 | — | — | US | disclosed |
| US-8598206-B2 | Trypsin-like serine protease inhibitors, and their preparation and use | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2013-12-03 | — | — | US | disclosed |
| EP-2528895-A2 | TRYPSIN-LIKE SERINE PROTEASE INHIBITORS, AND THEIR PREPARATION AND USE | The Medicines Company (Leipzig) GmbH (DE) | 2012-12-05 | — | — | EP | disclosed |
| US-20110301196-A1 | TRYPSIN-LIKE SERINE PROTEASE INHIBITORS, AND THEIR PREPARATION AND USE | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2011-12-08 | — | — | US | disclosed |
| WO-2011094496-A2 | TRYPSIN-LIKE SERINE PROTEASE INHIBITORS, AND THEIR PREPARATION AND USE | THE MEDICINES COMPANY (US) | 2011-08-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140073573-A1 | TRYPSIN-LIKE SERINE PROTEASE INHIBITORS, AND THEIR PREPARATION AND USE | SERPINE1, SPINT2, SERPINB1 | SMN1; SMN2 4122/4885NPC1 3283/4885RAB9A 3553/4885 |
| US-20110301196-A1 | TRYPSIN-LIKE SERINE PROTEASE INHIBITORS, AND THEIR PREPARATION AND USE | SERPINE1, SPINT2, SERPINB1 | SMN1; SMN2 4122/4885NPC1 3283/4885RAB9A 3553/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.