SCHEMBL8551044

SCHEMBL8551044

O=C(OCc1ccccc1)C1CCN(Cc2ccccc2)CC1

nearest known ligand 0.67

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.59
TSHR P16473 1/20 0.59
KMT2A Q03164 1/20 0.59
ALDH1A1 P00352 2/20 0.59
CCR8 P51685 1/20 0.59
NPC1 O15118 2/20 0.58
RAB9A P51151 2/20 0.58
SMN1; SMN2 Q16637 2/20 0.57
TP53 P04637 1/20 0.57
ABL1 P00519 1/20 0.56
RIN1 Q13671 1/20 0.56
KDM4E B2RXH2 2/20 0.55
MAPT P10636 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8550696 0.99 MEN1 (0.58) MEN1TSHRKMT2AALDH1A1CCR8
SCHEMBL24131658 0.92 L3MBTL1 (0.60) MEN1TSHRKMT2ANPC1RAB9A
SCHEMBL24131137 0.92 L3MBTL1 (0.60) MEN1TSHRKMT2ANPC1RAB9A
SCHEMBL608528 0.87 ALDH1A1 (0.76) TSHRKMT2AALDH1A1CCR8SMN1; SMN2
SCHEMBL8173819 0.87 SMN1; SMN2 (0.56) TSHRALDH1A1CCR8NPC1RAB9A
SCHEMBL3361971 0.86 EGFR (0.55) ALDH1A1CCR8NPC1RAB9ASMN1; SMN2
SCHEMBL14845464 0.86 HTR2A (0.64) ALDH1A1NPC1RAB9ASMN1; SMN2
Hydrochloric Acid SCHEMBL7438287 0.86 ALDH1A1 (0.74) KMT2AALDH1A1CCR8SMN1; SMN2KDM4E
SCHEMBL2356908 0.85 SMN1; SMN2 (0.52) TSHRKMT2AALDH1A1CCR8NPC1
SCHEMBL26454342 0.85 EGFR (0.59) ALDH1A1CCR8NPC1RAB9ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5753679-A SCIZOPHRENIA HOFFMANN-LA ROCHE INC. (US) 1998-05-19 US claimed
EP-3044223-B1 2,3-DIHYDRO-1H-INDEN-1-ONE DERIVATIVES AS RETINOIC ACID-RELATED ORPHAN RECEPTOR GAMMA (ROR GAMMA) ANTAGONISTS FOR TREATING MULTIPLE SCLEROSIS ARRIEN PHARMACEUTICALS LLC (US) 2020-04-01 EP disclosed
EP-0871613-A1 BENZYL PIPERIDINE DERIVATIVES AS PHARMACEUTICAL AGENTS F. HOFFMANN-LA ROCHE AG (CH) 1998-10-21 EP disclosed
US-5753679-A SCIZOPHRENIA HOFFMANN-LA ROCHE INC. (US) 1998-05-19 US disclosed
WO-1996035666-A1 BENZYL PIPERIDINE DERIVATIVES AS PHARMACEUTICAL AGENTS F.HOFFMANN-LA ROCHE AG (CH) 1996-11-14 WO disclosed