Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 2/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.41 |
| ▸ | PTGFR | P43088 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 4/20 | 0.41 |
| ▸ | PPARA | Q07869 | 4/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.41 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.40 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.39 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23570176 | 0.94 | SLC6A2 (0.48) | SLC6A2SLC6A4KCNH2SLC6A3ALDH1A1 | |
| SCHEMBL23570178 | 0.78 | SLC6A2 (0.45) | SLC6A2SLC6A4KCNH2SLC6A3ALDH1A1 | |
| SCHEMBL5842315 | 0.77 | SLC6A2 (0.50) | SLC6A2SLC6A4KCNH2SLC6A3PTGER3 | |
| SCHEMBL22809757 | 0.76 | ALDH1A1 (0.44) | SLC6A2SLC6A4KCNH2SLC6A3ALDH1A1 | |
| SCHEMBL5991434 | 0.75 | SCN8A (0.45) | SLC6A2SLC6A4KCNH2SLC6A3ALDH1A1 | |
| SCHEMBL6142365 | 0.74 | POLB (0.48) | SLC6A2SLC6A4KCNH2SLC6A3ALDH1A1 | |
| SCHEMBL1137899 | 0.74 | PTGER3 (0.60) | ALDH1A1HTTPTGER3PTGFR | |
| SCHEMBL4509584 | 0.73 | TDP1 (0.44) | SLC6A2SLC6A4KCNH2SLC6A3ALDH1A1 | |
| SCHEMBL22809753 | 0.72 | SCN8A (0.47) | SLC6A2SLC6A4KCNH2SLC6A3MRGPRX4 | |
| SCHEMBL30276641 | 0.71 | SLC6A2 (0.41) | SLC6A2SLC6A4KCNH2SLC6A3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127333-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |