Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TNKS | O95271 | 1/20 | 0.42 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | VCP | P55072 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2355147 | 0.84 | LMNA (0.44) | MAPTRXFP1TP53LMNAMEN1 | |
| SCHEMBL2362584 | 0.79 | POLB (0.61) | MAPTRXFP1TP53LMNAMEN1 | |
| SCHEMBL12024152 | 0.77 | HTT (0.58) | TP53LMNAMEN1HPGDKMT2A | |
| SCHEMBL2363650 | 0.73 | VCP (0.46) | MAPTRXFP1TP53LMNAMEN1 | |
| SCHEMBL2354757 | 0.69 | KMT2A (0.58) | MAPTRXFP1TP53LMNAMEN1 | |
| SCHEMBL11960890 | 0.67 | MAPK10 (0.63) | MAPTRXFP1LMNAMEN1HPGD | |
| SCHEMBL2357637 | 0.67 | CYP3A4 (0.61) | TP53LMNAMEN1KMT2APOLB | |
| SCHEMBL18568684 | 0.66 | POLB (0.59) | MAPTRXFP1TP53LMNAMEN1 | |
| SCHEMBL24533635 | 0.65 | CYP3A4 (0.60) | RXFP1TP53LMNAMEN1KMT2A | |
| SCHEMBL11961159 | 0.63 | TSHR (0.61) | MAPTRXFP1TP53LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3135672-B9 | COMPOSITIONS AND METHODS FOR TREATING ALCOHOL USE DISORDERS, PAIN AND OTHER DISEASES | VM DISCOVERY INC (US) | 2020-05-20 | — | — | EP | disclosed |
| EP-3135672-B1 | COMPOSITIONS AND METHODS FOR TREATING ALCOHOL USE DISORDERS, PAIN AND OTHER DISEASES | VM DISCOVERY INC (US) | 2020-02-19 | — | — | EP | disclosed |
| EP-3135672-B1 | COMPOSITIONS AND METHODS FOR TREATING ALCOHOL USE DISORDERS, PAIN AND OTHER DISEASES | VM DISCOVERY INC (US) | 2020-02-19 | — | — | EP | disclosed |
| EP-3135672-A1 | COMPOSITIONS AND METHODS FOR TREATING ALCOHOL USE DISORDERS, PAIN AND OTHER DISEASES | VM Discovery, Inc. (US) | 2017-03-01 | — | — | EP | disclosed |
| EP-3135672-A1 | COMPOSITIONS AND METHODS FOR TREATING ALCOHOL USE DISORDERS, PAIN AND OTHER DISEASES | VM Discovery, Inc. (US) | 2017-03-01 | — | — | EP | disclosed |
| EP-2356109-B1 | COMPOSITIONS AND METHODS FOR TREATING ALCOHOL USE DISORDERS, PAIN AND OTHER DISEASES | VM DISCOVERY INC (US) | 2016-12-07 | — | — | EP | disclosed |
| US-8729081-B2 | Compositions and methods for treating alcohol use disorders, pain and other diseases | VM DISCOVERY INC. (US) | 2014-05-20 | — | — | US | disclosed |
| US-8729081-B2 | Compositions and methods for treating alcohol use disorders, pain and other diseases | VM DISCOVERY INC. (US) | 2014-05-20 | — | — | US | disclosed |
| US-20110301149-A1 | COMPOSITIONS AND METHODS FOR TREATING ALCOHOL USE DISORDERS, PAIN AND OTHER DISEASES | VM DISCOVERY INC. (US) | 2011-12-08 | — | — | US | disclosed |
| US-20110301149-A1 | COMPOSITIONS AND METHODS FOR TREATING ALCOHOL USE DISORDERS, PAIN AND OTHER DISEASES | VM DISCOVERY INC. (US) | 2011-12-08 | — | — | US | disclosed |
| US-20110301149-A1 | COMPOSITIONS AND METHODS FOR TREATING ALCOHOL USE DISORDERS, PAIN AND OTHER DISEASES | VM DISCOVERY INC. (US) | 2011-12-08 | — | — | US | disclosed |
| EP-2356109-A2 | COMPOSITIONS AND METHODS FOR TREATING ALCOHOL USE DISORDERS, PAIN AND OTHER DISEASES | VM Discovery, Inc. (US) | 2011-08-17 | — | — | EP | disclosed |
| WO-2010042925-A2 | COMPOSITIONS AND METHODS FOR TREATING ALCOHOL USE DISORDERS, PAIN AND OTHER DISEASES | VM DISCOVERY INC. (US) | 2010-04-15 | — | — | WO | disclosed |
| WO-2010042925-A2 | COMPOSITIONS AND METHODS FOR TREATING ALCOHOL USE DISORDERS, PAIN AND OTHER DISEASES | VM DISCOVERY INC. (US) | 2010-04-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110301149-A1 | COMPOSITIONS AND METHODS FOR TREATING ALCOHOL USE DISORDERS, PAIN AND OTHER DISEASES | PRKCH, PRKCG, PRKCQ | MAPT 1539/4885RXFP1 3502/4885TP53 4665/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.