Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FASN | P49327 | 9/20 | 0.61 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | BRD2 | P25440 | 1/20 | 0.35 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 5/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 2/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2358391 | 0.93 | FASN (0.53) | FASNPAX8ROCK2DHODH | |
| SCHEMBL2356332 | 0.91 | FASN (0.49) | FASN | |
| SCHEMBL2355152 | 0.85 | FASN (0.42) | FASN | |
| SCHEMBL2355763 | 0.85 | FASN (0.46) | FASN | |
| SCHEMBL14151295 | 0.80 | FASN (0.85) | FASNBRD4BRD2BRD3ROCK2 | |
| SCHEMBL2299607 | 0.78 | FASN (0.81) | FASNROCK2HTT | |
| SCHEMBL2299601 | 0.78 | FASN (0.81) | FASNROCK2HTT | |
| SCHEMBL2356363 | 0.77 | FASN (0.79) | FASNHTT | |
| SCHEMBL2355089 | 0.76 | FASN (0.40) | FASNHTT | |
| SCHEMBL2355905 | 0.76 | FASN (1.00) | FASN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011103546-A1 | TRIAZOLONES AS FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2011-08-25 | — | — | WO | disclosed |