Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FASN | P49327 | 15/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.37 |
| ▸ | CFD | P00746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2355763 | 0.89 | FASN (0.46) | FASNGSK3BMAPK8MAPK9MAPK10 | |
| SCHEMBL2356751 | 0.82 | FASN (0.60) | FASN | |
| SCHEMBL2355089 | 0.81 | FASN (0.40) | FASN | |
| SCHEMBL14152399 | 0.79 | FASN (0.60) | FASNGSK3B | |
| SCHEMBL12426814 | 0.78 | FASN (0.59) | FASNGSK3B | |
| SCHEMBL14151834 | 0.78 | FASN (0.59) | FASNGSK3B | |
| SCHEMBL2297993 | 0.77 | FASN (0.61) | FASNGSK3B | |
| SCHEMBL2298006 | 0.77 | FASN (0.61) | FASNGSK3B | |
| SCHEMBL2357729 | 0.77 | FASN (0.57) | FASN | |
| SCHEMBL2356332 | 0.76 | FASN (0.49) | FASN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011103546-A1 | TRIAZOLONES AS FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2011-08-25 | — | — | WO | disclosed |