Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMO | O15229 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.35 |
| ▸ | UTS2R | Q9UKP6 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | PLK1 | P53350 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30036494 | 0.89 | MAPT (0.36) | TSHRHTTMEN1KMT2AMAPT | |
| SCHEMBL30183808 | 0.89 | MAPT (0.36) | TSHRHTTMEN1KMT2AMAPT | |
| SCHEMBL23578092 | 0.85 | TSHR (0.38) | TSHRHTTMEN1KMT2ALMNA | |
| SCHEMBL30183974 | 0.79 | KDM4E (0.39) | TSHRHTTMEN1KMT2ALMNA | |
| SCHEMBL19610509 | 0.77 | EGFR (0.47) | LMNAALDH1A1CYP3A4KDM4ERAB9A | |
| SCHEMBL23590651 | 0.75 | ALDH1A1 (0.46) | TSHRHTTMEN1KMT2AALDH1A1 | |
| SCHEMBL30035755 | 0.75 | ALDH1A1 (0.46) | TSHRHTTMEN1KMT2AALDH1A1 | |
| SCHEMBL30183967 | 0.75 | ALDH1A1 (0.46) | TSHRHTTMEN1KMT2AALDH1A1 | |
| SCHEMBL25387764 | 0.71 | MAPT (0.48) | TSHRHTTMAPTKMOALDH1A1 | |
| SCHEMBL23590845 | 0.70 | ALDH1A1 (0.43) | TSHRHTTMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021130731-A1 | SUBSTITUTED TRICYCLIC COMPOUNDS | LUPIN LIMITED (IN) | 2021-07-01 | — | — | WO | disclosed |