Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | RECQL | P46063 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PLK1 | P53350 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30183714 | 1.00 | ALDH1A1 (0.43) | ALDH1A1SIRT6KDM4EPOLBMAPT | |
| SCHEMBL29267734 | 0.90 | TSHR (0.44) | ALDH1A1SIRT6KDM4EPOLBMAPT | |
| SCHEMBL30183974 | 0.87 | KDM4E (0.39) | ALDH1A1SIRT6KDM4EPOLBMAPT | |
| SCHEMBL25387167 | 0.87 | CTRC (0.38) | ALDH1A1SIRT6KDM4EPOLBMAPT | |
| SCHEMBL25387764 | 0.86 | MAPT (0.48) | ALDH1A1MAPTHTTUSP2PLK1 | |
| SCHEMBL23577603 | 0.85 | MAPT (0.45) | ALDH1A1SIRT6KDM4EPOLBMAPT | |
| SCHEMBL30183808 | 0.83 | MAPT (0.36) | ALDH1A1SIRT6KDM4EPOLBMAPT | |
| SCHEMBL30036494 | 0.83 | MAPT (0.36) | ALDH1A1SIRT6KDM4EPOLBMAPT | |
| SCHEMBL17934416 | 0.82 | EGFR (0.46) | ALDH1A1KDM4EMAPT | |
| SCHEMBL30036618 | 0.81 | KDM4E (0.52) | ALDH1A1KDM4EMAPTKMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115605476-B | Substituted tricyclic compounds | 鲁宾有限公司 | 2024-05-24 | — | — | CN | disclosed |
| CN-115605476-A | Substituted tricyclic compounds | 鲁宾有限公司（IN） | 2023-01-13 | — | — | CN | disclosed |
| WO-2021130731-A1 | SUBSTITUTED TRICYCLIC COMPOUNDS | LUPIN LIMITED (IN) | 2021-07-01 | — | — | WO | disclosed |