Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | MPI | P34949 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | HSPA9 | P38646 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30183682 | 0.86 | SIRT6 (0.43) | SIRT6TDP1MPIHTTALDH1A1 | |
| SCHEMBL23591009 | 0.85 | ALDH1A1 (0.40) | SIRT6TDP1MPIHTTALDH1A1 | |
| SCHEMBL28965721 | 0.84 | ALDH1A1 (0.40) | SIRT6TDP1MPIHTTALDH1A1 | |
| SCHEMBL23577725 | 0.82 | SIRT6 (0.40) | SIRT6TDP1HTTALDH1A1POLB | |
| SCHEMBL28965697 | 0.82 | SIRT6 (0.44) | SIRT6TDP1MPIHTTALDH1A1 | |
| SCHEMBL29267771 | 0.82 | SIRT6 (0.39) | SIRT6TDP1HTTALDH1A1POLB | |
| SCHEMBL23577862 | 0.81 | SIRT6 (0.39) | SIRT6TDP1HTTALDH1A1POLB | |
| Potassium SCHEMBL30034793 | 0.81 | SIRT6 (0.39) | SIRT6TDP1HTTALDH1A1POLB | |
| SCHEMBL30184061 | 0.81 | SIRT6 (0.39) | SIRT6TDP1HTTALDH1A1POLB | |
| SCHEMBL30183710 | 0.80 | SIRT6 (0.40) | SIRT6TDP1HTTALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4081521-A1 | SUBSTITUTED TRICYCLIC COMPOUNDS | Lupin Limited (IN) | 2022-11-02 | — | — | EP | disclosed |
| WO-2021130731-A1 | SUBSTITUTED TRICYCLIC COMPOUNDS | LUPIN LIMITED (IN) | 2021-07-01 | — | — | WO | disclosed |