Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.47 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | APOL1 | O14791 | 1/20 | 0.35 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.34 |
| ▸ | MLNR | O43193 | 2/20 | 0.34 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23599583 | 0.82 | SLC1A2 (0.45) | SIGMAR1SLC1A2KCNH2CYP3A4FAAH | |
| SCHEMBL23579491 | 0.81 | CYP2D6 (0.35) | SIGMAR1SLC1A2KCNH2CYP3A4FAAH | |
| SCHEMBL21911488 | 0.81 | SIGMAR1 (0.48) | SIGMAR1CYP3A4FAAHCYP2D6TSHR | |
| SCHEMBL21910398 | 0.80 | SIGMAR1 (0.48) | SIGMAR1MEN1KMT2A | |
| SCHEMBL21910678 | 0.79 | SIGMAR1 (0.41) | SIGMAR1MEN1KMT2AMLNR | |
| SCHEMBL25896635 | 0.78 | SIGMAR1 (0.49) | SIGMAR1MEN1KMT2A | |
| SCHEMBL29995614 | 0.77 | TACR1 (0.37) | MEN1KMT2A | |
| SCHEMBL23579494 | 0.76 | SIGMAR1 (0.46) | SIGMAR1KCNH2MEN1KMT2A | |
| SCHEMBL21910684 | 0.73 | SIGMAR1 (0.46) | SIGMAR1KCNH2 | |
| SCHEMBL23578731 | 0.73 | MAPT (0.54) | SIGMAR1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12454531-B2 | Substituted piperazine derivatives useful as T cell activators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2025-10-28 | — | — | US | disclosed |
| CN-115175907-B | Substituted piperazine derivatives useful as T cell activators | 百时美施贵宝公司 | 2024-08-02 | — | — | CN | disclosed |
| US-20230118629-A1 | SUBSTITUTED PIPERAZINE DERIVATIVES USEFUL AS T CELL ACTIVATORS | BRISTOL MYERS SQUIBB CO (US) | 2023-04-20 | — | — | US | disclosed |
| US-20230118629-A1 | SUBSTITUTED PIPERAZINE DERIVATIVES USEFUL AS T CELL ACTIVATORS | BRISTOL MYERS SQUIBB CO (US) | 2023-04-20 | — | — | US | disclosed |
| CN-115175907-A | Substituted piperazine derivatives useful as T cell activators | 百时美施贵宝公司 | 2022-10-11 | — | — | CN | disclosed |
| WO-2021133749-A1 | SUBSTITUTED PIPERAZINE DERIVATIVES USEFUL AS T CELL ACTIVATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2021-07-01 | — | — | WO | disclosed |
| WO-2021133749-A1 | SUBSTITUTED PIPERAZINE DERIVATIVES USEFUL AS T CELL ACTIVATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2021-07-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230118629-A1 | SUBSTITUTED PIPERAZINE DERIVATIVES USEFUL AS T CELL ACTIVATORS | DGKZ, DGKA, DGKG | SIGMAR1 2423/4885SLC1A2 4407/4885KCNH2 1145/4885 |
| US-12454531-B2 | Substituted piperazine derivatives useful as T cell activators | DGKZ, DGKA, DGKG | SIGMAR1 2423/4885SLC1A2 4407/4885KCNH2 1145/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.