Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 2/20 | 0.34 |
| ▸ | FEN1 | P39748 | 2/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 2/20 | 0.30 |
| ▸ | JAK1 | P23458 | 2/20 | 0.30 |
| ▸ | BTK | Q06187 | 1/20 | 0.30 |
| ▸ | TYK2 | P29597 | 1/20 | 0.30 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.30 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.30 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.30 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23579437 | 1.00 | ALOX5AP (0.34) | ALOX5APFEN1SCN9APIK3CAHCRTR1 | |
| SCHEMBL23578855 | 1.00 | ALOX5AP (0.34) | ALOX5APFEN1SCN9APIK3CAHCRTR1 | |
| SCHEMBL23579445 | 0.92 | OPRM1 (0.33) | ALOX5APFEN1SCN9AHCRTR1HCRTR2 | |
| SCHEMBL23165655 | 0.92 | OPRM1 (0.33) | ALOX5APFEN1SCN9AHCRTR1HCRTR2 | |
| SCHEMBL23579454 | 0.92 | OPRM1 (0.33) | ALOX5APFEN1SCN9AHCRTR1HCRTR2 | |
| SCHEMBL29747346 | 0.85 | JAK2 (0.35) | ALOX5APFEN1JAK2JAK1TYK2 | |
| SCHEMBL25284683 | 0.83 | GRM5 (0.33) | ALOX5APFEN1PIK3CAJAK2JAK1 | |
| SCHEMBL23579290 | 0.83 | GRM5 (0.33) | ALOX5APFEN1PIK3CAJAK2JAK1 | |
| SCHEMBL23579340 | 0.83 | GRM5 (0.33) | ALOX5APFEN1PIK3CAJAK2JAK1 | |
| SCHEMBL21751548 | 0.82 | PRKCA (0.35) | ALOX5APFEN1SCN9AOPRM1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021133817-A1 | 1H-PYRROLO[2,3-B]PYRIDINE DERIVATIVES AS BCL-2 INHIBITORS FOR THE TREATMENT OF NEOPLASTIC AND AUTOIMMUNE DISEASES | Guangzhou Lupeng Pharmaceutical Company Ltd. (CN) | 2021-07-01 | — | — | WO | disclosed |