Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KA | P42356 | 4/20 | 0.57 |
| ▸ | PI4K2B | Q8TCG2 | 4/20 | 0.57 |
| ▸ | PI4K2A | Q9BTU6 | 4/20 | 0.57 |
| ▸ | PI4KB | Q9UBF8 | 4/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.57 |
| ▸ | BLM | P54132 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | APEX1 | P27695 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.57 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.53 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.53 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.53 |
| ▸ | ADA | P00813 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23584557 | 0.86 | ALDH1A1 (0.43) | PI4KAPI4K2BPI4K2API4KBMAPK1 | |
| SCHEMBL19941993 | 0.85 | PI4KA (0.59) | PI4KAPI4K2BPI4K2API4KBMAPK1 | |
| SCHEMBL20419221 | 0.84 | ADA (0.65) | PI4KAPI4K2BPI4K2API4KBMAPK1 | |
| SCHEMBL22460508 | 0.84 | PI4KA (0.57) | PI4KAPI4K2BPI4K2API4KBMAPK1 | |
| SCHEMBL8094890 | 0.84 | ADA (0.65) | PI4KAPI4K2BPI4K2API4KBMAPK1 | |
| SCHEMBL9197787 | 0.84 | ADA (0.65) | PI4KAPI4K2BPI4K2API4KBMAPK1 | |
| SCHEMBL24221343 | 0.84 | PI4KA (0.57) | PI4KAPI4K2BPI4K2API4KBMAPK1 | |
| SCHEMBL24909980 | 0.84 | PI4KA (0.57) | PI4KAPI4K2BPI4K2API4KBMAPK1 | |
| SCHEMBL20711187 | 0.84 | PI4KA (0.57) | PI4KAPI4K2BPI4K2API4KBMAPK1 | |
| SCHEMBL1374909 | 0.84 | ADA (0.65) | PI4KAPI4K2BPI4K2API4KBMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3426664-B1 | SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-06-30 | — | — | EP | disclosed |