Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ALB | P02768 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 3/20 | 0.41 |
| ▸ | RIN1 | Q13671 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | PI4KA | P42356 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.40 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.40 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23584692 | 0.86 | PI4KA (0.57) | ALDH1A1MAPK1LMNAALBCYP1A2 | |
| SCHEMBL2035453 | 0.84 | ALDH1A1 (0.60) | ALDH1A1MAPK1LMNAALBABL1 | |
| SCHEMBL2035452 | 0.84 | ALDH1A1 (0.60) | ALDH1A1MAPK1LMNAALBABL1 | |
| SCHEMBL24600957 | 0.84 | ALDH1A1 (0.60) | ALDH1A1MAPK1LMNAALBABL1 | |
| SCHEMBL23584826 | 0.83 | YTHDC1 (0.55) | — | |
| SCHEMBL27574575 | 0.81 | BCHE (0.44) | ALDH1A1MAPK1LMNAALBABL1 | |
| SCHEMBL23584461 | 0.80 | PRMT5 (0.38) | MEN1 | |
| SCHEMBL19003220 | 0.79 | BCHE (0.43) | ALDH1A1MAPK1LMNAALBABL1 | |
| SCHEMBL24021920 | 0.79 | ALDH1A1 (0.47) | ALDH1A1MAPK1LMNAALBABL1 | |
| SCHEMBL12652428 | 0.77 | BCHE (0.43) | ALDH1A1MAPK1LMNAALBCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3426664-B1 | SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-06-30 | — | — | EP | disclosed |