Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 8/20 | 0.44 |
| ▸ | WDR77 | Q9BQA1 | 6/20 | 0.44 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.35 |
| ▸ | ADK | P55263 | 1/20 | 0.35 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22524104 | 0.85 | PRMT5 (0.48) | PRMT5WDR77YTHDC1ADK | |
| SCHEMBL23584460 | 0.85 | PRMT5 (0.42) | PRMT5WDR77YTHDC1ADKPIP4K2A | |
| SCHEMBL23584701 | 0.83 | ADK (0.46) | PRMT5WDR77ADKSIGMAR1 | |
| SCHEMBL23584461 | 0.83 | PRMT5 (0.38) | PRMT5WDR77ADKHRH3 | |
| SCHEMBL23584826 | 0.81 | YTHDC1 (0.55) | YTHDC1 | |
| SCHEMBL23584625 | 0.80 | PRMT5 (0.36) | PRMT5WDR77 | |
| SCHEMBL23892515 | 0.76 | PRMT5 (0.44) | PRMT5WDR77YTHDC1ADKPIP4K2A | |
| SCHEMBL23584471 | 0.75 | MEN1 (0.46) | PRMT5WDR77ADKHRH3 | |
| SCHEMBL23584681 | 0.75 | HRH3 (0.41) | PRMT5WDR77HRH3 | |
| SCHEMBL23584695 | 0.74 | PRMT5 (0.39) | PRMT5WDR77ADK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3426664-B1 | SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-06-30 | — | — | EP | disclosed |