Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.47 |
| ▸ | RAF1 | P04049 | 1/20 | 0.45 |
| ▸ | HCK | P08631 | 1/20 | 0.44 |
| ▸ | NR2C2 | P49116 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.44 |
| ▸ | BRAF | P15056 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 4/20 | 0.43 |
| ▸ | BCR | P11274 | 4/20 | 0.43 |
| ▸ | NR2E1 | Q9Y466 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2357417 | 0.94 | ABL1 (0.47) | CSF1REPHB2RAF1HCKNR2C2 | |
| SCHEMBL2359009 | 0.89 | EPHB2 (0.53) | CSF1REPHB2RAF1HCKNR2C2 | |
| SCHEMBL2358401 | 0.89 | BRAF (0.46) | CSF1REPHB2RAF1HCKNR2C2 | |
| SCHEMBL12433483 | 0.88 | CSF1R (0.62) | CSF1REPHB2RAF1HCKNR2C2 | |
| SCHEMBL2365076 | 0.86 | KDM4E (0.44) | CSF1REPHB2RAF1HCKNR2C2 | |
| SCHEMBL2359059 | 0.86 | EPHB2 (0.50) | CSF1REPHB2RAF1HCKNR2C2 | |
| SCHEMBL2357420 | 0.84 | ABL1 (0.51) | CSF1REPHB2RAF1HCKNR2C2 | |
| SCHEMBL12433883 | 0.84 | CSF1R (0.59) | CSF1REPHB2RAF1HCKNR2C2 | |
| SCHEMBL19057073 | 0.82 | ABL1 (0.49) | RAF1BRAFABL1BCRNR2E1 | |
| SCHEMBL14717868 | 0.81 | CSF1R (0.59) | CSF1REPHB2RAF1HCKNR2C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2528925-A2 | THIENO[3,2-d]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY ON PROTEIN KINASES | Hanmi Science Co., Ltd. (KR) | 2012-12-05 | — | — | EP | disclosed |
| WO-2011093684-A2 | THIENO[3,2-d]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY ON PROTEIN KINASES | HANMI HOLDINGS CO., LTD. (KR) | 2011-08-04 | — | — | WO | disclosed |