Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.30 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.30 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.30 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.30 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2360808 | 1.00 | METAP2 (0.30) | METAP2CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL2361211 | 1.00 | METAP2 (0.30) | METAP2CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL2325868 | 0.88 | CTSS (0.34) | — | |
| SCHEMBL2325866 | 0.88 | CTSS (0.34) | — | |
| SCHEMBL2322778 | 0.79 | — | — | |
| SCHEMBL2326208 | 0.79 | — | — | |
| SCHEMBL2323097 | 0.79 | — | — | |
| SCHEMBL5048364 | 0.78 | CTSS (0.32) | — | |
| SCHEMBL5048357 | 0.78 | CTSS (0.32) | — | |
| SCHEMBL3611699 | 0.78 | REN (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081927-B1 | PIPERIDINE DERIVATIVES AS RENIN INHIBITORS | VITAE PHARMACEUTICALS INC (US) | 2011-08-17 | — | — | EP | claimed |