Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.33 |
| ▸ | HTR3B | O95264 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.33 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | GABRP | O00591 | 1/20 | 0.32 |
| ▸ | GABRD | O14764 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2359406 | 0.77 | KDM4E (0.51) | ALDH1A1KDM4EHPGDKMT2AMEN1 | |
| SCHEMBL4143598 | 0.73 | ALDH1A1 (0.38) | DAOALDH1A1KDM4EHPGDKMT2A | |
| SCHEMBL28014515 | 0.72 | RPS6KA5 (0.47) | KDM4E | |
| SCHEMBL8312594 | 0.71 | KDM4E (0.66) | ALDH1A1KDM4EHPGDKMT2AMEN1 | |
| SCHEMBL4135731 | 0.68 | ALDH1A1 (0.43) | DAOALDH1A1KDM4EHPGDKMT2A | |
| SCHEMBL1446732 | 0.68 | LTA4H (0.38) | DAOALDH1A1KMT2AMEN1HTR3E | |
| SCHEMBL2299818 | 0.68 | KMT2A (0.45) | ALDH1A1KDM4EKMT2AMEN1HTR3E | |
| SCHEMBL10681757 | 0.62 | GABRA5 (0.36) | ALDH1A1KDM4EHPGDKMT2AHTR3E | |
| SCHEMBL5571659 | 0.62 | PARP1 (0.47) | DAOKDM4EKMT2AMEN1LMNA | |
| SCHEMBL11301840 | 0.62 | IDO1 (0.49) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3661936-A1 | [1,2,4]TRIAZOLO[4,3-A]PYRAZIN-6(5H)-ONE DERIVATIVES | Eli Lilly and Company (US) | 2020-06-10 | — | — | EP | disclosed |
| WO-2019027783-A1 | [1,2,4]TRIAZOLO[4,3-A]PYRAZIN-6(5H)-ONE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2019-02-07 | — | — | WO | disclosed |