Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 5/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.34 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.34 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | GAPDH | P04406 | 1/20 | 0.34 |
| ▸ | CASP6 | P55212 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | RYR2 | Q92736 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2474337 | 0.81 | MAPK1 (0.46) | NAMPTNOTUM | |
| SCHEMBL1388134 | 0.78 | KDM4E (0.43) | NOTUMRIPK1ALDH1A1HDAC8 | |
| SCHEMBL16207990 | 0.77 | TSHR (0.38) | NAMPTNOTUMRIPK1ALDH1A1CACNA1G | |
| SCHEMBL9851802 | 0.73 | CYP11B2 (0.41) | NOTUMRIPK1CYP11B2ALDH1A1OPRK1 | |
| SCHEMBL29758685 | 0.72 | NOTUM (0.64) | NAMPTNOTUMHSP90AA1HSP90AB1NPC1 | |
| SCHEMBL2533362 | 0.72 | NOTUM (0.64) | NAMPTNOTUMHSP90AA1HSP90AB1NPC1 | |
| SCHEMBL11778334 | 0.72 | CYP11B2 (0.54) | RIPK1CYP11B2ALDH1A1OPRK1PDE4D | |
| SCHEMBL29500932 | 0.70 | CYP1A2 (0.44) | NOTUMRIPK1CYP11B2ALDH1A1OPRK1 | |
| SCHEMBL21061364 | 0.69 | CYP11B2 (0.45) | NOTUMCYP11B2ALDH1A1OPRK1PDE4D | |
| SCHEMBL29500960 | 0.69 | CYP11B2 (0.36) | NOTUMRIPK1CYP11B2ALDH1A1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2356123-A1 | SPIRO-5,6-DIHYDRO-4H-2,3,5,10B-TETRAAZA-BENZO[E]AZULENES | F. Hoffmann-La Roche AG (CH) | 2011-08-17 | — | — | EP | claimed |