Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.35 |
| ▸ | MAT2A | P31153 | 5/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | PLK1 | P53350 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | MPI | P34949 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23576646 | 0.88 | MAT2A (0.39) | EGFRKDRPDGFRBGRM4MAT2A | |
| SCHEMBL29909742 | 0.88 | MAT2A (0.39) | EGFRKDRPDGFRBGRM4MAT2A | |
| SCHEMBL23601318 | 0.81 | PDGFRB (0.38) | EGFRKDRPDGFRBMAT2APRMT5 | |
| SCHEMBL23601397 | 0.81 | EGFR (0.38) | EGFRKDRPDGFRBMAT2APRMT5 | |
| SCHEMBL29909381 | 0.80 | PDGFRB (0.36) | EGFRKDRPDGFRBMAT2APRMT5 | |
| SCHEMBL23576826 | 0.80 | PDGFRB (0.36) | EGFRKDRPDGFRBMAT2APRMT5 | |
| SCHEMBL24721479 | 0.77 | PDGFRB (0.35) | EGFRKDRPDGFRBMAT2APRMT5 | |
| SCHEMBL24806307 | 0.77 | MAPT (0.40) | EGFRKDRPDGFRBGRM4MAT2A | |
| SCHEMBL23577196 | 0.77 | PDGFRB (0.38) | EGFRKDRPDGFRBMAT2APRMT5 | |
| SCHEMBL29909162 | 0.77 | PDGFRB (0.38) | EGFRKDRPDGFRBMAT2APRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021130638-A1 | DIACYLGLYCEROL KINASE MODULATING COMPOUNDS | CARNA BIOSCIENCES, INC. (JP) | 2021-07-01 | — | — | WO | disclosed |