Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 5/20 | 0.66 |
| ▸ | METAP2 | P50579 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.39 |
| ▸ | FEN1 | P39748 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | DHFR | P00374 | 3/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2643156 | 0.79 | MAP4K4 (1.00) | MAP4K4METAP2KIT | |
| SCHEMBL20150481 | 0.78 | MAP4K4 (0.68) | MAP4K4ALOX5APFEN1MAPTDHFR | |
| SCHEMBL6561405 | 0.78 | METAP2 (0.50) | METAP2APPCHRNB4CHRNA3PDE4A | |
| SCHEMBL17667718 | 0.76 | MAP4K4 (0.66) | MAP4K4ALOX5APFEN1LMNAMAPT | |
| SCHEMBL17667716 | 0.76 | MAP4K4 (0.66) | MAP4K4ALOX5APFEN1LMNAMAPT | |
| SCHEMBL24341918 | 0.76 | MAP4K4 (0.66) | MAP4K4ALOX5APFEN1LMNAMAPT | |
| SCHEMBL13040 | 0.76 | MAP4K4 (0.66) | MAP4K4METAP2 | |
| SCHEMBL5322145 | 0.76 | MAP4K4 (0.66) | MAP4K4DHFR | |
| SCHEMBL23601919 | 0.76 | EGLN2 (0.42) | MAP4K4METAP2APPCHRNB4CHRNA3 | |
| SCHEMBL17547086 | 0.75 | ATM (0.54) | MAP4K4METAP2APPCHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021130638-A1 | DIACYLGLYCEROL KINASE MODULATING COMPOUNDS | CARNA BIOSCIENCES, INC. (JP) | 2021-07-01 | — | — | WO | disclosed |