Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | METAP2 | P50579 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13681264 | 0.79 | CTSS (0.49) | EGLN2METAP2MAP4K4HPGD | |
| SCHEMBL17742851 | 0.77 | EGLN2 (0.39) | EGLN2APPMETAP2MAP4K4ALDH1A1 | |
| SCHEMBL1509663 | 0.77 | RAB9A (0.54) | EGLN2ALDH1A1TDP1NPSR1KDM4E | |
| SCHEMBL23601920 | 0.76 | MAP4K4 (0.66) | APPMETAP2MAP4K4CHRNB4CHRNA3 | |
| SCHEMBL24721275 | 0.75 | IDO1 (0.45) | EGLN2MAP4K4ALDH1A1TDP1NPSR1 | |
| SCHEMBL6241000 | 0.75 | CTSS (0.54) | ALDH1A1KDM4EL3MBTL1GAA | |
| SCHEMBL9020421 | 0.74 | EGLN2 (0.44) | EGLN2MAP4K4ALDH1A1TDP1NPSR1 | |
| SCHEMBL24648525 | 0.73 | CLK4 (0.53) | EGLN2MAP4K4CLK4GABRG2GABRB3 | |
| SCHEMBL6561405 | 0.73 | METAP2 (0.50) | APPMETAP2CHRNB4CHRNA3CYP1A2 | |
| SCHEMBL18874389 | 0.72 | CLK4 (0.43) | METAP2MAP4K4CHRNB4CHRNA3CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021130638-A1 | DIACYLGLYCEROL KINASE MODULATING COMPOUNDS | CARNA BIOSCIENCES, INC. (JP) | 2021-07-01 | — | — | WO | disclosed |