Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23609070 | 0.92 | TDP1 (0.48) | EGLN3TDP1ALDH1A1GFERMEN1 | |
| SCHEMBL18072326 | 0.78 | EGLN3 (0.53) | EGLN3ALDH1A1MEN1KMT2ANAMPT | |
| SCHEMBL16050434 | 0.77 | TDP1 (0.43) | TDP1ALDH1A1GFERMEN1GAA | |
| SCHEMBL13088472 | 0.77 | ALDH1A1 (0.43) | TDP1ALDH1A1GFERMEN1GAA | |
| SCHEMBL28230841 | 0.77 | TDP1 (0.43) | TDP1ALDH1A1GFERMEN1GAA | |
| SCHEMBL173977 | 0.75 | TDP1 (0.47) | TDP1ALDH1A1GFERMEN1GAA | |
| SCHEMBL18072248 | 0.74 | EGLN3 (0.53) | EGLN3MEN1GAAKMT2ANAMPT | |
| SCHEMBL20445070 | 0.74 | EGLN3 (0.53) | EGLN3MEN1GAAKMT2ANAMPT | |
| SCHEMBL13975444 | 0.74 | LMNA (0.47) | TDP1ALDH1A1GFERMEN1GAA | |
| SCHEMBL28230811 | 0.74 | ALDH1A1 (0.42) | TDP1ALDH1A1GFERMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022093856-A1 | HETEROCYCLIC SPIRO COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2022-05-05 | — | — | WO | disclosed |
| WO-2021133689-A2 | LIPOXYGENASE INHIBITORS | SRI INTERNATIONAL (US) | 2021-07-01 | — | — | WO | disclosed |
| CN-108472284-A | β -lactamase inhibitor | 维纳拓尔斯制药公司 | 2018-08-31 | — | — | CN | disclosed |
| CN-108290878-A | NOVEL FERROPORTIN INHIBITORS | 威佛（国际）股份公司 | 2018-07-17 | — | — | CN | disclosed |