Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 8/20 | 0.50 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | CPT2 | P23786 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12247049 | 0.92 | EPHX1 (0.58) | EPHX1PRMT1KDM4EMAPK1HIF1A | |
| SCHEMBL28269014 | 0.85 | EPHX1 (0.73) | EPHX1EPHX2 | |
| SCHEMBL21706216 | 0.84 | SIGMAR1 (0.41) | EPHX1PRMT1DRD2DRD3 | |
| SCHEMBL13046404 | 0.83 | EPHX1 (0.50) | EPHX1PRMT1KDM4EMAPK1HIF1A | |
| SCHEMBL23613547 | 0.80 | EPHX1 (0.49) | EPHX1PRMT1KDM4EMAPK1HIF1A | |
| SCHEMBL22040075 | 0.80 | EPHX1 (0.43) | EPHX1PRMT1KDM4EMAPK1HIF1A | |
| SCHEMBL13617133 | 0.80 | KEAP1 (0.49) | EPHX1PRMT1KDM4EMAPK1HIF1A | |
| SCHEMBL19698261 | 0.78 | EPHX1 (0.49) | EPHX1PRMT1KDM4EMAPK1HIF1A | |
| SCHEMBL2824552 | 0.78 | BCHE (0.36) | EPHX1DRD2DRD3EPHX2 | |
| SCHEMBL21016313 | 0.78 | KDM4E (0.70) | EPHX1KDM4EMAPK1HIF1ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11718626-B2 | Macrocyclic compounds for treatment of medical disorders | ACHILLION PHARMACEUTICALS, INC. (US) | 2023-08-08 | — | — | US | disclosed |
| US-20210300934-A1 | MACROCYCLIC COMPOUNDS FOR TREATMENT OF MEDICAL DISORDERS | ACHILLION PHARMACEUTICALS, INC. | 2021-09-30 | — | — | US | disclosed |
| US-11053253-B2 | Macrocyclic compounds for treatment of medical disorders | ACHILLION PHARMACEUTICALS, INC. (US) | 2021-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11718626-B2 | Macrocyclic compounds for treatment of medical disorders | CFD, TFPI, CFH | EPHX1 1257/4885PRMT1 2191/4885KDM4E 3629/4885 |
| US-11053253-B2 | Macrocyclic compounds for treatment of medical disorders | CFD, TFPI, CFH | EPHX1 1257/4885PRMT1 2191/4885KDM4E 3629/4885 |
| US-20210300934-A1 | MACROCYCLIC COMPOUNDS FOR TREATMENT OF MEDICAL DISORDERS | CFD, TFPI, CFH | EPHX1 1257/4885PRMT1 2191/4885KDM4E 3629/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.