Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.37 |
| ▸ | MLYCD | O95822 | 2/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | MMP8 | P22894 | 1/20 | 0.34 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.33 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.33 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20883279 | 0.87 | EPHX1 (0.51) | CYP2D6CYP2C19EPHX1CES2KMT2A | |
| SCHEMBL20883265 | 0.87 | EPHX1 (0.51) | CYP2D6CYP2C19EPHX1CES2KMT2A | |
| SCHEMBL25939803 | 0.81 | CES2 (0.39) | EPHX1MLYCDCES2KMT2AMEN1 | |
| SCHEMBL23613286 | 0.78 | PLA2G2C (0.35) | CYP2D6CYP2C19EPHX1MLYCDCES2 | |
| SCHEMBL9153250 | 0.76 | HPGD (0.47) | CYP2D6CYP2C19EPHX1MMP1MMP8 | |
| SCHEMBL9162003 | 0.76 | HPGD (0.47) | CYP2D6CYP2C19EPHX1MMP1MMP8 | |
| SCHEMBL24340731 | 0.73 | CYP2D6 (0.45) | CYP2D6CYP2C19EPHX1MLYCDMMP1 | |
| SCHEMBL7444194 | 0.72 | CYP2D6 (0.52) | CYP2D6CYP2C19EPHX1MLYCDMMP1 | |
| SCHEMBL17660269 | 0.72 | HPGD (0.50) | CYP2D6CYP2C19EPHX1MMP1MMP8 | |
| SCHEMBL21970957 | 0.71 | CNR2 (0.39) | CYP2D6CYP2C19MLYCDCNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11053253-B2 | Macrocyclic compounds for treatment of medical disorders | ACHILLION PHARMACEUTICALS, INC. (US) | 2021-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11053253-B2 | Macrocyclic compounds for treatment of medical disorders | CFD, TFPI, CFH | CYP2D6 216/4885CYP2C19 127/4885EPHX1 1257/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.