Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.33 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.33 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.33 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23615998 | 0.91 | HIF1A (0.48) | HIF1AALDH1A1MAPTNPSR1SMYD3 | |
| SCHEMBL23615933 | 0.76 | CYP2D6 (0.44) | HIF1AALDH1A1MAPTKDM4ENPC1 | |
| SCHEMBL19675453 | 0.70 | MAPT (0.50) | HIF1AALDH1A1MAPTNPSR1KDM4E | |
| SCHEMBL24751622 | 0.66 | PPARG (0.40) | HIF1AALDH1A1LMNA | |
| SCHEMBL27249154 | 0.61 | CHKA (0.51) | ALDH1A1MAPTKDM4ENPC1TP53 | |
| SCHEMBL18118174 | 0.61 | HPGD (0.52) | ALDH1A1MAPTNPSR1KDM4ENPC1 | |
| SCHEMBL15893978 | 0.61 | HIF1A (0.58) | HIF1AALDH1A1MAPTNPSR1KDM4E | |
| SCHEMBL16564077 | 0.61 | HTT (0.57) | ALDH1A1MAPTNPSR1KDM4ENPC1 | |
| SCHEMBL28745217 | 0.61 | MAPT (0.54) | HIF1AALDH1A1MAPTNPSR1KDM4E | |
| SCHEMBL10473871 | 0.61 | KMT2A (0.47) | ALDH1A1MAPTNPSR1KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3845516-A1 | NOVEL HIF-1alfa INHIBITOR, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING ANGIOGENESIS-ASSOCIATED EYE DISEASE, CONTAINING SAME AS ACTIVE INGREDIENT | Seoul National University R & DB Foundation (KR) | 2021-07-07 | — | — | EP | disclosed |