Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23615998 | 0.82 | HIF1A (0.48) | HIF1AMAPTKMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL10473871 | 0.80 | KMT2A (0.47) | CYP2D6CHRM2ADRA2BADRA2CCHRM3 | |
| SCHEMBL300433 | 0.78 | CHKA (0.56) | CYP2D6MAPTKMT2AMEN1CYP2C19 | |
| SCHEMBL18618234 | 0.78 | CHKA (0.56) | CYP2D6MAPTKMT2AMEN1CYP2C19 | |
| Hydrochloric Acid SCHEMBL29156885 | 0.76 | MEN1 (0.55) | CYP2D6MAPTKMT2AMEN1CYP2C19 | |
| SCHEMBL2056142 | 0.76 | KDM4E (0.57) | CYP2D6MAPTKMT2AMEN1CYP2C19 | |
| SCHEMBL23615939 | 0.76 | HIF1A (0.42) | HIF1AMAPTKMT2AALDH1A1ALOX15 | |
| SCHEMBL19675453 | 0.75 | MAPT (0.50) | HIF1AMAPTKMT2AMEN1L3MBTL1 | |
| SCHEMBL24715763 | 0.73 | KDM4E (0.57) | CYP2D6MAPTKMT2AMEN1CYP2C19 | |
| SCHEMBL27565323 | 0.70 | ALDH1A1 (0.53) | HIF1AMAPTKMT2AMEN1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3845516-A1 | NOVEL HIF-1alfa INHIBITOR, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING ANGIOGENESIS-ASSOCIATED EYE DISEASE, CONTAINING SAME AS ACTIVE INGREDIENT | Seoul National University R & DB Foundation (KR) | 2021-07-07 | — | — | EP | disclosed |