Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | STAT1 | P42224 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23615939 | 0.91 | HIF1A (0.42) | HIF1AMAPTALDH1A1NPSR1SMYD3 | |
| SCHEMBL23615933 | 0.82 | CYP2D6 (0.44) | HIF1AMAPTALDH1A1KDM4EALOX15 | |
| SCHEMBL19675453 | 0.76 | MAPT (0.50) | HIF1AMAPTALDH1A1NPSR1KDM4E | |
| SCHEMBL23615963 | 0.68 | BCHE (0.31) | HIF1A | |
| SCHEMBL15893978 | 0.67 | HIF1A (0.58) | HIF1AMAPTALDH1A1NPSR1KDM4E | |
| SCHEMBL28745217 | 0.67 | MAPT (0.54) | HIF1AMAPTALDH1A1NPSR1KDM4E | |
| SCHEMBL27530982 | 0.66 | AKR1C3 (0.45) | ALOX15TSHRLMNA | |
| SCHEMBL10473871 | 0.66 | KMT2A (0.47) | MAPTALDH1A1NPSR1KDM4EALOX15 | |
| SCHEMBL1599647 | 0.66 | MAPT (0.45) | MAPTALDH1A1NPSR1KDM4EALOX15 | |
| SCHEMBL24590678 | 0.66 | ALDH1A1 (0.51) | MAPTALDH1A1NPSR1KDM4EALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3845516-A1 | NOVEL HIF-1alfa INHIBITOR, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING ANGIOGENESIS-ASSOCIATED EYE DISEASE, CONTAINING SAME AS ACTIVE INGREDIENT | Seoul National University R & DB Foundation (KR) | 2021-07-07 | — | — | EP | disclosed |