Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.31 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1571887 | 0.74 | KDM4E (0.39) | KDM4E | |
| SCHEMBL3279288 | 0.74 | EGFR (0.34) | EGFR | |
| SCHEMBL747251 | 0.69 | MMP2 (0.35) | EGFRKDM4E | |
| SCHEMBL28665764 | 0.67 | — | — | |
| SCHEMBL3854510 | 0.67 | KDM4E (0.37) | KDM4E | |
| SCHEMBL367523 | 0.63 | EGFR (0.32) | EGFR | |
| SCHEMBL29204081 | 0.63 | PKM (0.30) | — | |
| SCHEMBL5800131 | 0.63 | TNF (0.34) | KDM4E | |
| SCHEMBL13979159 | 0.62 | HTT (0.39) | KDM4E | |
| SCHEMBL6870185 | 0.61 | ALDH1A1 (0.52) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1333833-B1 | Novel trisubstituted-8H-pyrido[2,3-d]pyrimidin-7-one compound for the treatment of CSBP/p38 kinase mediated diseases | GLAXOSMITHKLINE LLC (US) | 2011-08-24 | — | — | EP | disclosed |
| EP-1333833-A4 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2007-10-24 | — | — | EP | disclosed |
| EP-1333833-A2 | NOVEL COMPOUNDS | SmithKline Beecham Corporation (US) | 2003-08-13 | — | — | EP | disclosed |
| WO-2002059083-A3 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2003-04-10 | — | — | WO | disclosed |
| WO-2002059083-A2 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-08-01 | — | — | WO | disclosed |