Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Pyridine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.83 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.64 |
| ▸ | MEN1 | O00255 | 3/20 | 0.64 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | PABPC1 | P11940 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | PLOD2 | O00469 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2776368 | 0.91 | ALDH1A1 (0.94) | ALDH1A1KMT2AMEN1RAB9APABPC1 | |
| Bromide SCHEMBL7402288 | 0.91 | ALDH1A1 (1.00) | ALDH1A1KMT2AMEN1RAB9APABPC1 | |
| Bromide SCHEMBL122633 | 0.91 | ALDH1A1 (1.00) | ALDH1A1KMT2AMEN1RAB9APABPC1 | |
| Bromide SCHEMBL7402285 | 0.90 | ALDH1A1 (0.97) | ALDH1A1KMT2AMEN1RAB9APABPC1 | |
| SCHEMBL1444452 | 0.90 | ALDH1A1 (0.97) | ALDH1A1KMT2AMEN1RAB9APABPC1 | |
| Bromide SCHEMBL28819589 | 0.88 | ALDH1A1 (0.94) | ALDH1A1KMT2AMEN1RAB9APABPC1 | |
| Bromide SCHEMBL3854856 | 0.83 | ALDH1A1 (0.83) | ALDH1A1KMT2AMEN1RAB9APABPC1 | |
| Bromide SCHEMBL6227813 | 0.79 | KMT2A (1.00) | ALDH1A1KMT2AMEN1RAB9APABPC1 | |
| Bromide SCHEMBL5907542 | 0.78 | KMT2A (0.69) | ALDH1A1KMT2AMEN1RAB9APABPC1 | |
| Bromide SCHEMBL3849524 | 0.77 | ALDH1A1 (0.72) | ALDH1A1KMT2AMEN1RAB9APABPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2359146-A1 | NON-ENZYMATIC ELECTROCHEMICAL METHOD FOR SIMULTANEOUS DETERMINATION OF TOTAL HEMOGLOBIN AND GLYCATED HEMOGLOBIN | Piramal Healthcare Limited (IN) | 2011-08-24 | — | — | EP | disclosed |
| WO-2010043985-A1 | NON-ENZYMATIC ELECTROCHEMICAL METHOD FOR SIMULTANEOUS DETERMINATION OF TOTAL HEMOGLOBIN AND GLYCATED HEMOGLOBIN | PIRAMAL HEALTHCARE LIMITED (IN) | 2010-04-22 | — | — | WO | disclosed |