Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.94 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | PABPC1 | P11940 | 2/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1444452 | 0.98 | ALDH1A1 (0.97) | ALDH1A1KMT2AMEN1RAB9APABPC1 | |
| Bromide SCHEMBL7402288 | 0.97 | ALDH1A1 (1.00) | ALDH1A1KMT2AMEN1RAB9APABPC1 | |
| Bromide SCHEMBL122633 | 0.97 | ALDH1A1 (1.00) | ALDH1A1KMT2AMEN1RAB9APABPC1 | |
| Bromide SCHEMBL28819589 | 0.97 | ALDH1A1 (0.94) | ALDH1A1KMT2AMEN1RAB9APABPC1 | |
| Bromide SCHEMBL7402285 | 0.95 | ALDH1A1 (0.97) | ALDH1A1KMT2AMEN1RAB9APABPC1 | |
| Pyridine SCHEMBL2361689 | 0.91 | ALDH1A1 (0.83) | ALDH1A1KMT2AMEN1RAB9APABPC1 | |
| Bromide SCHEMBL3854856 | 0.88 | ALDH1A1 (0.83) | ALDH1A1KMT2AMEN1RAB9APABPC1 | |
| SCHEMBL7074123 | 0.82 | ALDH1A1 (0.69) | ALDH1A1KMT2AMEN1RAB9APABPC1 | |
| SCHEMBL6936032 | 0.82 | ALDH1A1 (0.69) | ALDH1A1KMT2AMEN1RAB9APABPC1 | |
| SCHEMBL6935140 | 0.82 | ALDH1A1 (0.69) | ALDH1A1KMT2AMEN1PABPC1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2475757-A2 | PREVENTION OF BODY ODOUR | Henkel AG & Co. KGaA (DE) | 2012-07-18 | — | — | EP | claimed |
| US-20120164097-A1 | PREVENTION OF BODY ODOUR | HENKEL AG & CO. KGAA (DE) | 2012-06-28 | — | — | US | claimed |
| WO-2011029688-A2 | PREVENTION OF BODY ODOUR | HENKEL AG & CO. KGAA (DE) | 2011-03-17 | — | — | WO | claimed |
| WO-2010031657-A2 | USE OF UREA DERIVATIVES AND PHENACYLTHIAZOLIUM SALTS FOR THE TREATMENT OF BODY ODOUR | HENKEL AG & CO. KGAA (DE) | 2010-03-25 | — | — | WO | claimed |
| US-9217222-B2 | Prevention of body odour | HENKEL AG & CO. KGAA (DE) | 2015-12-22 | — | — | US | disclosed |
| EP-2475757-A2 | PREVENTION OF BODY ODOUR | Henkel AG & Co. KGaA (DE) | 2012-07-18 | — | — | EP | disclosed |
| US-20120164097-A1 | PREVENTION OF BODY ODOUR | HENKEL AG & CO. KGAA (DE) | 2012-06-28 | — | — | US | disclosed |
| WO-2011029688-A2 | PREVENTION OF BODY ODOUR | HENKEL AG & CO. KGAA (DE) | 2011-03-17 | — | — | WO | disclosed |
| WO-2010031657-A2 | USE OF UREA DERIVATIVES AND PHENACYLTHIAZOLIUM SALTS FOR THE TREATMENT OF BODY ODOUR | HENKEL AG & CO. KGAA (DE) | 2010-03-25 | — | — | WO | disclosed |
| US-7511036-B2 | Dihydrothiazine prodrugs of thiazolium agents | SYNVISTA THERAPEUTICS, INC. (US) | 2009-03-31 | — | — | US | disclosed |
| US-20070054901-A1 | Dihydrothiazine prodrugs of thiazolium agents | SYNVISTA THERAPEUTICS, INC. | 2007-03-08 | — | — | US | disclosed |
| EP-1622885-A2 | DIHYDROTHIAZINE PRODRUGS OF THIAZOLIUM AGENTS | ALTEON, INC. (US) | 2006-02-08 | — | — | EP | disclosed |
| US-20050014747-A1 | Dihydrothiazine prodrugs of thiazolium agents | ALTEON INC. | 2005-01-20 | — | — | US | disclosed |
| WO-2004094396-A2 | DIHYDROTHIAZINE PRODRUGS OF THIAZOLIUM AGENTS | ALTEON, INC. (US) | 2004-11-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050014747-A1 | Dihydrothiazine prodrugs of thiazolium agents | DHPS, HRH4, CYP8B1 | ALDH1A1 439/4885KMT2A 822/4885MEN1 339/4885 |
| US-20070054901-A1 | Dihydrothiazine prodrugs of thiazolium agents | DHPS, HRH4, CYP8B1 | ALDH1A1 439/4885KMT2A 822/4885MEN1 339/4885 |
| US-20120164097-A1 | PREVENTION OF BODY ODOUR | CUTA, NOTUM, SLC14A1 | ALDH1A1 642/4885KMT2A 3258/4885MEN1 2867/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.